Indiana vs. Michigan State Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 3:04 p.m. ET

Data Skrive

The No. 3 Indiana Hoosiers (6-0) host the Michigan State Spartans (3-3) on Saturday, October 18, 2025 in a matchup between Big Ten rivals at Memorial Stadium (Bloomington, IN). Michigan State is a 26.5-point underdog. The over/under is set at 49.5.

The Hoosiers beat the Oregon Ducks, 30-20, in their last game. Last time out, the Spartans fell to the UCLA Bruins, with 38-13 being the final score.

Keep up with college football all season on FOX Sports.

Indiana vs. Michigan State Game Information & Odds

When: Saturday, October 18, 2025 at 3:30 p.m. ET
Location: Memorial Stadium (Bloomington, IN) in Bloomington, Indiana
TV: Peacock
Live Box Score on FOX Sports

Indiana vs Michigan State Betting Information updated as of October 18, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Indiana	-26.5 (-109)	-4762	+1590	49.5	-110	-110

Indiana vs. Michigan State Prediction

Pick ATS: Indiana (-26.5)
Pick OU: Over (49.5)
Prediction: Indiana 50, Michigan State 7

Predictions are made by the Data Skrive betting model.

Learn more about the Indiana Hoosiers vs. the Michigan State Spartans game on FOX Sports!

Indiana vs. Michigan State Betting Insights

Based on the spread and over/under, the implied score for the game is Hoosiers 38, Spartans 12.
The Hoosiers have a 97.9% chance to win this game based on the moneyline's implied probability. The Spartans hold a 5.9% implied probability.
Indiana has compiled a 4-2-0 ATS record so far this year.
Michigan State has a record of 2-4-0 against the spread this season.

Indiana vs. Michigan State: Head-to-Head

Indiana and Michigan State have been matched up evenly over their last four matchups, sharing the same 2-2 record.
In their past four head-to-head meetings, each team has covered two times with those games outscoring the point total on two occasions.
Michigan State has been outpaced by 37 points in its last four tilts against Indiana.

Indiana vs. Michigan State: 2025 Stats Comparison

	Indiana	Michigan State
Off. Points per Game (Rank)	44.8 (4)	29.5 (65)
Def. Points per Game (Rank)	11.3 (4)	31.8 (116)
Turnovers Allowed (Rank)	3 (6)	8 (76)
Turnovers Forced (Rank)	10 (30)	5 (104)

Indiana 2025 Key Players

Name	Position	Stats
Fernando Mendoza	QB	1,423 YDS (71.2%) / 17 TD / 2 INT 133 RUSH YDS / 2 RUSH TD / 22.2 RUSH YPG
Omar Cooper Jr.	WR	30 REC / 490 YDS / 6 TD / 81.7 YPG
Elijah Sarratt	WR	38 REC / 509 YDS / 7 TD / 84.8 YPG
Roman Hemby	RB	421 YDS / 2 TD / 70.2 YPG / 5 YPC 7 REC / 101 REC YDS / 0 REC TD / 20.2 REC YPG
Isaiah Jones	LB	26 TKL / 8 TFL / 4.5 SACK / 1 INT
Louis Moore	DB	31 TKL / 2 TFL / 3 INT / 3 PD
Aiden Fisher	LB	31 TKL / 4 TFL / 2.5 SACK
Kellan Wyatt	DL	23 TKL / 6 TFL / 2.5 SACK

Michigan State 2025 Key Players

Name	Position	Stats
Aidan Chiles	QB	1,019 YDS (61.3%) / 9 TD / 3 INT 186 RUSH YDS / 5 RUSH TD / 31 RUSH YPG
Nick Marsh	WR	29 REC / 340 YDS / 4 TD / 56.7 YPG
Makhi Frazier	RB	383 YDS / 2 TD / 63.8 YPG / 4.4 YPC
Omari Kelly	WR	24 REC / 347 YDS / 1 TD / 57.8 YPG
Jordan Hall	LB	43 TKL / 3 TFL / 2 SACK / 1 INT
Malik Spencer	DB	25 TKL / 3 TFL / 2 SACK
Wayne Matthews III	LB	35 TKL / 1 TFL / 1 INT / 1 PD
Armorion Smith	DB	20 TKL / 0 TFL / 1 INT / 1 PD