Iowa State vs. Lipscomb Prediction, Odds, Picks - NCAA Tournament First Round

Updated Mar. 21, 2025 10:27 a.m. ET

Data Skrive

A first-round NCAA Tournament matchup will see the No. 3-seed Iowa State Cyclones (24-9) hit the court against the No. 14 seed Lipscomb Bisons (25-9) on Friday at Fiserv Forum. The contest tips off at 1:30 p.m. ET, on TNT.

The Cyclones are a double-digit favorite against the Bisons when the Cyclones and the Bisons square off. The Cyclones are favored by 14.5 points. The matchup's over/under is set at 143.5.

Keep reading to get all the information before betting on the Iowa State-Lipscomb matchup.

Iowa State vs. Lipscomb Game Information & Odds

When: Friday, March 21, 2025 at 1:30 p.m. ET
Where: Fiserv Forum in Milwaukee, Wisconsin
How to watch on TV: TNT
Live boxscore on FOX Sports

Cyclones vs Bisons Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Cyclones	-14.5	-105	-115	143.5	-110	-120	-1351	+800

Iowa State vs. Lipscomb Prediction

Pick ATS: Lipscomb (+14.5)
Pick OU: Over (143.5)
Prediction: Iowa State 80, Lipscomb 67

Learn more about the Iowa State Cyclones vs. the Lipscomb Bisons game on FOX Sports!

Iowa State vs. Lipscomb Betting Insights

Betting Line Implied Predictions

Per the spread and over/under, the implied score for the matchup is Cyclones 79, Bisons 64.
The Cyclones have a 93.1% chance to win this contest per the moneyline's implied probability.
The Bisons hold an 11.1% implied probability to win.

Key Spread Facts

Iowa State has compiled a 19-14-0 ATS record so far this year.
Lipscomb has put together a 17-13-1 record against the spread this season.
Iowa State has an ATS record of 5-6 when playing as at least 14.5-point favorites this season.
Lipscomb has not covered the spread when an underdog by 14.5 points or more this season (in two opportunities).

Key Total Facts

Cyclones games have finished with more than 143.5 points 16 times so far this year.
So far this season, 15 Bisons games have featured over 143.5 points scored.
The Cyclones and Bisons average 159.7 points per game combined, which is 16.2 more than the over/under for this matchup.

Key Moneyline Facts

Iowa State has been favored on the moneyline 24 times this season. They've gone 19-5 in those games.
Lipscomb has been underdogs in seven games this season and won two (28.6%) of those contests.
Iowa State has gone 6-1 when playing as a moneyline favorite with odds of -1351 or shorter (winning 85.7%).
Lipscomb has played as an underdog of +800 or more once this season and lost that game.

Iowa State vs. Lipscomb: 2024-25 Stats Comparison

	Iowa State	Lipscomb
Points Scored Per Game (Rank)	80.4 (34)	79.3 (51)
Points Allowed (Rank)	68.1 (63)	67.3 (49)
Rebounds (Rank)	8.8 (181)	7 (324)
3pt Made (Rank)	7.7 (173)	9.9 (27)
Assists (Rank)	15 (79)	15.1 (76)
Turnovers (Rank)	11.5 (219)	9.1 (12)

Iowa State 2024-25 Key Players

Cyclones Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Curtis Jones	32	17.1	4.3	2.3	1.2	0.2	2.6
Keshon Gilbert	29	13.4	3.5	4.1	1.7	0.1	0.9
Joshua Jefferson	33	13	7.4	3	2.1	0.7	0.5
Milan Momcilovic	26	11.4	3.2	0.9	0.4	0.3	2.2
Tamin Lipsey	32	10.8	2.6	3.2	2.1	0.2	1.2

Lipscomb 2024-25 Key Players

Bisons Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Jacob Ognacevic	34	20.1	8.1	1.4	0.3	0.4	1.4
Will Pruitt	34	13.2	5.9	2.6	0.9	0.3	1.4
Joe Anderson	34	12.4	3.6	3.9	2.3	0.2	2.2
Gyasi Powell	34	11.7	3.6	1.4	1	0.1	2.2
Dylan Faulkner	15	10.5	5.3	2	0.5	1.6	0