The Gunners will be looking to get their Premier League title challenge back on track when Rovers visit the Emirates, and they have been boosted by the news that their Dutch striker is fit to feature.
Van Persie returned from the international break with a minor knee problem he suffered during Tuesday's 5-3 win over Hungary, but initial fears have improved.
Wenger said: "He's all right. He will be in the squad.
"He had a kick on his knee and he had a test this morning - if there is no reaction overnight he should be okay.
"I'm an optimist so there is always the hope that it will not be too severe. That was the case, for once we had good news.
"It's the final part of the season, losing a player now is basically like losing them for the rest of the season.
"We are in the final sprint for the championship so you want all your players available.
"What will decide it will be our performances until the end of the season and therefore you want your key players."