Holder Paris Saint-Germain reached the round of 16 of the French Cup with a 3-2 win at fifth-division club Agen on Sunday.
Following its defeat in the League Cup semifinals at Montpellier earlier this week, Antoine Kombouare's team struggled on a bad pitch but bounced back with goals from Mathieu Bodmer, Peguy Luyindula and Guillaume Hoarau.
Mamoudou Daffe and Anthony Vandersnick scored for Agen.
Kombouare was delighted by Luyindula's performance after the two had an angry exchange this week over the player's role at the club. Luyindula, who had refused to play at Montpellier, started the match against Agen.
"I'm only interested in seeing him play with fighting spirit, with a great state of mind, and I want him to show his qualities," Kombouare said. "He worked hard and was rewarded with a goal. Sometimes there are tensions within the group, but he responded well."
Rennes and Lille also advanced, while Lyon lost 1-0 at Nice in the only match between first-division teams. Nice defender Francois Clerc scored the winner in extra time against his former club.
Lyon finished with 10 men after Dejan Lovren was sent off in the 99th minute for a second yellow card.
"We lifted our game to their level. Lyon is a very good team and we struggled, that's normal, but we fought hard," said Clerc, a former France international who signed a two-year contract with Nice in September after leaving Lyon in bad terms.
Alexander Tettey and Yacine Brahimi scored second-half goals as Rennes beat sixth-division side Vaulx-en-Velin 2-0.
Tettey opened Rennes' account in the 50th minute when he met Jires Kembo's cross in the area before Brahimi beat goalkeeper Eddie Rion from close range in the 74th.
Vaulx-en-Velin, the lowest ranked club left in the competition, matched Rennes' possession and created several chances, forcing goalkeeper Nicolas Douchez to make two decisive saves in the last 30 minutes.
Brazilian forward Tulio de Mello headed the winner from Ludovic Obraniak's free kick in the 40th minute as league leader Lille continued its impressive form with a 1-0 win over fifth-division Wasquehal in a northern derby.
"We knew it could have been complicated," Lille coach Rudi Garcia said. "We reached our goal, we went through and that's the main thing."
Lille has won seven of its last eight games in all competitions.
On Saturday, Brest and Bordeaux joined the list of first-division teams eliminated. Brest lost 4-3 in a penalty shootout to fifth-division side Chambery while second-division Angers defeated Bordeaux 1-0.
