Shrewsbury, who play in the fourth tier of English football, will host Premier League leaders Chelsea in the fourth round of the Capital One Cup.
Chelsea were 2-1 winners over Bolton on Wednesday night and will now travel to the New Meadow in Shropshire, Shrewsbury having beaten Norwich 1-0 on Tuesday night.
And there will definitely be a League One side in the last eight because MK Dons have been drawn at home to Sheffield United.
Holders Manchester City thrashed Sheffield Wednesday 7-0 in their third round tie at the Etihad and will be at home again in round four, when they will host an all Premier League tie against Newcastle.
There are two other all-Premier League contests in the form of Stoke v Southampton and Liverpool v Swansea.
Brighton face a tough trip to Tottenham but fellow Championship outfit Bournemouth will fancy their chances of causing an upset at home to West Brom.
Fulham and Derby were the last teams out in the draw, meaning there will definitely be Championship representation in the last eight.
Capital One Cup fourth round draw:
Tottenham v Brighton
Stoke v Southampton
Bournemouth v West Brom
Shrewsbury v Chelsea
Liverpool v Swansea
MK Dons v Sheffield United
Manchester City v Newcastle
Fulham v Derby
Ties to be played October 28-29.
