Jamie Thomas gave the visitors an early lead as they looked to complete the group campaign with their perfect record intact, but second-half strikes from Judelin Aveska and Kervens Belfort Fils turned the game on its head.
Also in Group F, Curacao completed their campaign with a 6-1 thumping of bottom team the US Virgin Islands.
Shannon Carmelia and Richmar Siberie grabbed a brace apiece while Everon Espacia and Angelo Cijntje were also on target for the hosts, who cruised to victory despite the dismissal of Rugenio Josephia four minutes before half-time.
Keithroy Cornelius netted the visitors' consolation five minutes into the second half - only their second goal in qualifying - but they finished the group stage without a point on the board.
Elsewhere, goals from Olivier Occean, Dwayne De Rosario (penalty), Josh Simpson and Tosaint Ricketts earned Group D winners Canada a comfortable home win over St Kitts and Nevis.
Group C winners Panama also closed out the campaign in style with a 3-0 home triumph over Dominica, thanks to goals from Rolando Blackburn, Ricardo Buitrago and substitute Blas Perez.
Group A winners El Salvador finished on a high with a 4-0 win over Suriname, Osael Romero and substitute Rafael Burgos bagging two goals apiece.
Second-half goals from Kenwyne Jones and Lester Peltier secured Trinidad & Tobago a 2-0 win over Group B winners Guyana.
In Group E, pool winners Guatemala completed the campaign with a 100% record thanks to a 4-1 triumph in Grenada.
Shane Rennie had put the hosts ahead with a 37th-minute penalty but it all went wrong for Grenada following the 61st-minute dismissal of Cassim Langaigne.
A Michael Mark own goal restored parity before further strikes from Fredy Thompson, Guillermo Ramirez and Angelo Padilla sealed an emphatic away win.
Finally, Belize won 2-0 in St Vincent and The Grenadines.
