Campeonato Brasileiro leader Corinthians suffered just its second defeat of the season as it slipped to a 3-2 reverse at Avai - which claimed its second win of the campaign.
Corinthians took the lead on the half-hour mark through Emerson's effort, but William levelled three minutes after the restart and a double from Rafael Coelho put the host in control.
Jorge Henrique pulled one back in the last minute but it was not enough.
It was also a bad day for Sao Paulo, which slipped to third Sunday thanks to Flamengo's win and could not go back into second as it slipped to a 2-0 home defeat against Vasco da Gama.
Eder Luis opened the scoring seven minutes after the break and Felipe made the points safe in stoppage time.
Fluminense strolled to a 4-0 win over 10-man Ceara.
Flu was 1-0 up through Fred when Heleno was dismissed on the stroke of half-time, and the host added to its tally through Souza, Rafael Sobis and Rafael Moura.
Marcos Aurelio scored twice as Coritiba won 3-1 at America MG.
Bill scored the other for the visitors, while Kempes pulled one back briefly to make it 2-1.
Struggling Santos lost again, slipping to a 3-2 defeat at Atletico Paranaense.
It was 2-0 down inside 10 minutes through Cleber Santana and Manoel before Neymar pulled one back.
Borges evened things up just after the hour mark but Marcinho handed his side the points with a goal in stoppage time.
Reinaldo, Avine and Jones scored for Bahia in a 3-1 win over Figueirense, for whom Wellington netted, while Internacional and Atletico Goianiense drew 0-0.
