Offensive tackle Lane Johnson injured his left knee on the Eagles' opening drive and did not return to the team's 24-18 win over the Jaguars in London on Sunday.
And cornerback Jalen Mills injured his foot a minute into the third quarter and missed the rest of the game.
Johnson was an All-Pro at right tackle last season when the Eagles won the Super Bowl.
Chiefs wide receiver Tyreek Hill appeared to tweak his groin on a long catch early in the game and he left late in the fourth quarter. Linebacker Anthony Hitchens (ribs) and Frank Zombo (hamstring) also left late in Kansas City's 30-23 win over Denver.
Bears guard Kyle Long had to be helped off the field in the closing minutes with an injured right foot, putting a damper on a 24-10 victory over the New York Jets. Long was hurt when tight end Dion Sims rolled into him as the two were blocking for Jordan Howard on a run, adding to a long list of injuries for the star lineman.
And tight end Ben Braunecker left because of a concussion.
For the Jets, tight end Neal Sterling left with a concussion in the second quarter when he got hit by Chicago's Kyle Fuller after making a catch. And defensive lineman Steve McLendon suffered an ankle injury.
Bengals guard Clint Boling hurt his back late in the first half and defensive end Carl Lawson hurt his right knee in Cincinnati's 37-34 win over Tampa Bay. Buccaneers running back Ronald Jones II suffered a hamstring injury in the second half.
The 49ers lost two important defensive players in their 18-15 loss to the Cardinals. Linebacker Reuben Foster left early with a hamstring injury and safety Jaquiski Tartt was knocked out with a shoulder injury.
Redskins offensive tackle Trent Williams left with a dislocated thumb. Running back Kapri Bibbs (dislocated shoulder), safety Troy Apke (hamstring) and linebacker Ryan Anderson (sprained knee, MCL) were hurt during the 20-13 win over the Giants. Giants right tackle Chad Wheeler left in the second half with an ankle injury and was replaced by Brian Mihalik.
Steelers cornerback Coty Sensabaugh left with a foot injury in the second half of a 33-18 win over the Browns.
Cleveland running back Duke Johnson injured his leg while running after a screen pass on the game's second play.
