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The Buffalo Bills could be without running back LeSean McCoy in the opening round of the playoffs.
McCoy was carted off the field with a right ankle injury in the third quarter of Sunday's 22-16 victory at Miami.
After being tackled, he pounded the turf with his fist as trainers attended to him. He had 10 yards on 11 carries, giving him 1,138 yards rushing on the season.
McCoy's injury might be the most significant one to watch heading into wild-card weekend. The Bills (9-7) play at Jacksonville (10-6) on Sunday.
It will be Buffalo's first postseason game since the 1999 season. The Bills ended the longest playoff drought in North American pro sports.
Buffalo right tackle Jordan Mills (ankle) was helped off the field late in the second quarter.
Arizona tight end Jermaine Gresham tore his right Achilles against Seattle, creating doubt about his ability to return in time for the start of the 2018 season.
San Francisco receiver Marquise Goodwin sustained a concussion on a vicious hit by Los Angeles Rams safety Blake Countess, who likely will be fined.
Jacksonville safety Barry Church (hamstring) left the loss at Tennessee in the second half and did not return.
Carolina hopes to get running back Jonathan Stewart back next week against New Orleans. Stewart was inactive against Atlanta because of back tightness. The Panthers also were without two more starters: safety Kurt Coleman (ankle) and right guard Trai Turner (concussion).
Kansas City lost backup punt returner De'Anthony Thomas, who was carted off after injuring his right leg on the final play of the first quarter at Denver. Chiefs cornerback Phillip Gaines was knocked out with an elbow injury just before halftime.
Denver safety Will Parks went out in the fourth quarter with a neck injury.
Oakland safety Karl Joseph injured a hamstring in the first half. Defensive lineman Eddie Vanderdoes had to be helped off the field in the fourth quarter.
Miami linebacker LB Kiko Alonso suffered a neck injury.
Tampa Bay safety T.J. Ward left with a knee injury and did not play in the second half. Offensive tackle Caleb Benenoch injured an ankle in the first half but returned. He limped off for good with a sore knee in the second half.
Seattle guard Ethan Pocic injured a knee, and linebacker Terence Garvin sustained a concussion.
Washington running back Samaje Perine (ankle) and left tackle Ty Nsekhe (knee) were injured against the New York Giants, who lost guard John Jerry (concussion).
Green Bay receiver Geronimo Allison left in the first quarter with a finger injury and returned to play for a banged-up team minus receivers Davante Adams and Jordy Nelson because of injuries.
Detroit running back Theo Riddick (ribs), cornerback Teez Tabor (shoulder) and safety Don Carey (knee) were hurt against the Packers.
Houston receiver DeAndre Hopkins (calf) missed the first game of his NFL career, leaving four catches short of his second 100-reception season. Houston took another hit when receiver Will Fuller departed with a left knee injury on the first offensive series. Linebacker Jelani Jenkins left with a hamstring injury in the third quarter and did not return.
Indianapolis lost safety Kenny Moore (concussion) in the first half.
Minnesota fullback C.J. Ham hurt his neck and was ruled out early in the third quarter.
New York Jets safety Marcus Maye limped off the field in the second quarter with an ankle injury and did not return. Receiver Robby Anderson left after a fourth-quarter hit from Stephon Gilmore and was diagnosed with a concussion.
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