Akron (1-2) played without starting quarterback Chris Jacquemain, who was suspended indefinitely on Friday for a violation of team rules. Sophomore Matt Rodgers started, but without Jacquemain, a three-year starter, the Zips struggled moving the ball.
Austin Thomas had two of Indiana's four interceptions and the Hoosiers' defense held the Zips to 271 yards of total offense.
The Hoosiers are 3-0 for the third time in the last five years.
Prior to kickoff, a moment of silence was observed in honor of NCAA president Myles Brand, who died this week of pancreatic cancer. Brand was Indiana's president from 1994 to 2002.