Michigan vs. Iowa State Prediction, Odds, Picks – Women's Basketball NCAA Tournament First Round 2025

An opening-round NCAA Tournament matchup will see the 6-seed Michigan Wolverines (22-10) play as a 2.5-point favorite against the No. 11 seed Iowa State Cyclones (23-11) on Friday at Purcell Pavilion. The matchup tips off at 11:30 a.m. ET on ESPN2. Here's a look into this 6-11 matchup before filling out your brackets. The matchup has an over/under set at 149.5 points.

Michigan vs. Iowa State Game Info

• Game day: Friday, March 21, 2025
• Game time: 11:30 a.m. ET
• TV channel: ESPN2
• Follow this game live on FOX Sports

Michigan vs. Iowa State Odds

Michigan vs. Iowa State Prediction

• Computer Pick ATS: Iowa State (+2.5)
  
• Computer Pick OU: Under (149.5)
  
• Computer Prediction: Michigan 73, Iowa State 71

Learn more about the Michigan Wolverines vs. the Iowa State Cyclones game on FOX Sports!

Michigan Betting Insights

• The Wolverines' record against the spread is 12-12-0.
• Michigan is 6-7 ATS as 2.5-point favorites or more.
• This season, 12 of the Wolverines' 24 games have hit the over.
• This season, Michigan has won nine out of the 12 games, or 75%, in which it has been the moneyline favorite.
• The Wolverines have a record of 9-3 in games where bookmakers favor them by at least -142 on the moneyline.

Iowa State Betting Insights

• The Cyclones' record against the spread is 10-17-0.
• Iowa State has an ATS record of 3-6 as a 2.5-point underdog or more.
• This year, 16 of the Cyclones' 27 games have hit the over.
• Iowa State has won in one of the 10 contests it has been named as the moneyline underdog this year.
• This year, the Cyclones have won one of nine games when listed as at least +120 or worse on the moneyline.

Michigan's Top Performers

Iowa State's Top Performers

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.