Steelers vs. Bengals 2025 Prediction, Odds, Picks - Oct 16

The Pittsburgh Steelers (4-1) will be trying to extend a three-game winning run against the Cincinnati Bengals (2-4). The Steelers are the favorites, expected to win by at least a field goal but less than a touchdown (currently -5.5). The total for this one is set at 45.5 points.

Keep up with the 2025 NFL season on FOX Sports.

Should people buy stock in the Steelers & Aaron Rodgers’s 4-1 start? | The Herd

The Pittsburgh Steelers play the Cincinnati Bengals tonight, and have the potential to start the season 5-1. Colin Cowherd asks Steelers fans to relax based on the Steelers’ mostly easy schedule to start the year.

Steelers vs. Bengals Odds & Betting Lines

Steelers vs. Bengals Prediction & Pick

• Pick ATS: Steelers (-5.5)
  
• Pick OU: Over (45.5)
  
• Prediction: Steelers 27 - Bengals 19

How to Watch Pittsburgh vs. Cincinnati

• Game date: Thursday, October 16, 2025
• Time: 8:15 p.m. ET
• Venue: Paycor Stadium
• Location: Cincinnati, Ohio
• TV: Amazon Prime Video
• Live Boxscore: FOX Sports

Steelers vs. Bengals Recent Matchups

• Pittsburgh holds a 3-2 record against Cincinnati in their last five matchups.
• Cincinnati has been outpaced by 26 points in its last five tilts versus Pittsburgh.

Pittsburgh Betting Info

• Pittsburgh has played five games, posting three wins against the spread.
• The Steelers have won their only game this season when playing as at least 5.5-point favorites.
• Pittsburgh contests this year have eclipsed the over/under 60% of the time (three times in five games with a set point total).
• When playing as the moneyline favorite, the Steelers have won 75% of the time (3-1).
• Looking at this contest's moneyline, the Steelers' implied win probability is 73.5%.

Steelers Stats

Pittsburgh's Key Players

Offense

• Aaron Rodgers has 1,021 passing yards, 10 touchdowns (ninth in the NFL) and three interceptions this year. He has completed 68.8% of his passes, averaging 204.2 yards per game and 7.4 per attempt.
• D.K. Metcalf has 19 catches for 356 yards and four TDs. Through five games, he is averaging 3.8 catches and 71.2 yards per game.
• Kenneth Gainwell has 176 rushing yards with three touchdowns (35.2 yards per game through five games).
• Gainwell has gotten 22 targets in the passing game and has 19 catches (3.8 per game) for 79 yards (15.8 per game) and zero TDs.
• In the running game, Jaylen Warren averages 3.4 yards per attempt (39th in the NFL) and 46.0 yards per game for 184 total rushing yards. He's still looking for his first rushing TD of the season.
• Warren has been targeted 14 times to the tune of 13 catches, 153 yards and one TD.

Defense

• Over on the defensive side, T.J. Watt has 24 tackles, 5.0 TFL, 3.5 sacks, and one interception in 2025.
• Payton Wilson has 38 tackles, 5.0 TFL, and one sack this season. He's second on the Steelers in tackles.
• Nick Herbig has totaled 12 tackles, 6.0 TFL, 4.5 sacks, and one interception this year.
• Patrick Queen has 44 tackles, 5.0 TFL, one sack, and three passes defended.

Cincinnati Betting Info

• Cincinnati is 2-4-0 against the spread this year.
• The Bengals have covered the spread once this season when underdogs by 5.5 points or more (in three chances).
• This year, four Cincinnati games have gone over the point total.
• The Bengals have been listed as the underdog four times this season and have failed to win any of those games.
• The moneyline for this contest implies a 30.8% chance of a victory for the Bengals.

Bengals Stats

Cincinnati's Key Players

Offense

• Ja'Marr Chase has registered 468 receiving yards (fifth in the NFL) and four touchdowns (sixth in the NFL) on 42 receptions (fifth in the NFL), while being targeted 57 times this season.
• Jake Browning has 757 passing yards, six touchdowns and eight interceptions. His completion percentage is 64.5% and he averages 189.3 yards per game and 6.1 per attempt.
• He has also added 39 rushing yards (third on the Bengals), with one touchdown on the ground (averaging 9.8 yards per game and 4.3 per carry).
• In five games this season, Joe Flacco has amassed 1,034 passing yards, while throwing four touchdowns against six interceptions and completing 59.5% of his passes.
• Chase Brown puts up 33.7 rushing yards per game over six games (202 total yards), with one rushing touchdown.
• Brown has also caught 20 passes for 102 yards (fifth on the Bengals). He's been targeted 24 times and averages 17.0 yards per game.

Defense

• In 2025, Demetrius Knight II has put up 1.0 TFL, 46 tackles, and one interception through six games.
• Daxton Hill has totaled 1.0 TFL, 40 tackles, and one interception over six games.
• During the 2025 campaign, Geno Stone has 37 tackles, 2.0 TFL, one sack, and one interception in six games.
• Jordan Battle's stats include two interceptions (fifth in the NFL) as well as 45 tackles and two passes defended in six games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Cincinnati Bengals

Pittsburgh Steelers