Rays vs. Orioles Prediction, Odds, Picks - September 25

The Tampa Bay Rays versus Baltimore Orioles game on Thursday at 1:05 p.m. ET will showcase a pair of hot hitters in Yandy Diaz and Gunnar Henderson. Bookmakers list the Rays as -115 favorites on the moneyline, while giving the underdog Orioles -104 moneyline odds to win. Tampa Bay is the run-line favorite (-1.5). The matchup's over/under is set at 8.5 runs.

Here's everything you need from a betting perspective on the Rays-Orioles game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Rays vs. Orioles Highlights | MLB on FOX

Enjoy the best moments between the Tampa Bay Rays and the Baltimore Orioles.

Rays vs. Orioles Game Information & Odds

• When: Thursday, September 25, 2025 at 1:05 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN and FDSSUN

Rays vs. Orioles Prediction

• Score Prediction: Orioles 6, Rays 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Rays 50%, Orioles 50%

Rays vs. Orioles Betting Insights

• This season, the Rays have been favored 79 times and won 44, or 55.7%, of those games.
• Tampa Bay is 37-28 this season when entering a game favored by -115 or more on the moneyline.
• The implied probability of a win from the Rays, based on the moneyline, is 53.5%.
• The Orioles have been chosen as underdogs in 90 games this year and have walked away with the win 41 times (45.6%) in those games.
• This season, Baltimore has come away with a win 36 times in 82 chances when named as an underdog of at least -104 or worse on the moneyline.
• The Orioles have an implied victory probability of 51% according to the moneyline set for this matchup.

Rays Recent Betting Performance

• The Rays were the moneyline favorite three times over the last 10 games, but they lost each matchup.
• In their last 10 outings -- all had a set run total -- the Rays and their opponents combined to hit the over on the total four times.
• The Rays' ATS record is 7-3-0 over their past 10 games.

Rays Recent Stats

Rays Player Insights

• Junior Caminero paces the Rays in home runs (44) and runs batted in (109).
• Among all hitters in baseball, Caminero's home run total places him sixth, and his RBI tally ranks him sixth.
• Diaz has a club-leading .301 batting average.
• Diaz is 46th in homers in the majors, and 41st in RBI.
• Brandon Lowe is batting .258 with 19 doubles, 31 home runs and 37 walks.
• Chandler Simpson has 14 doubles, three triples and 20 walks while hitting .300.
• Simpson has recorded at least one hit in three straight games. During his last five outings he is batting .364 with a double and two RBIs.

Rays Team Props

Orioles Recent Betting Performance

• The Orioles have played as underdogs in seven of their past 10 games and won three of those contests.
• In their last 10 games with a total, the Orioles and their opponents have failed to hit the over eight times.
• The Orioles have won four of their last 10 games against the spread.

Orioles Recent Stats

Orioles Player Insights

• Henderson has posted a team-leading batting average of .272 while pacing the Orioles in runs batted in with a mark of 67.
• Henderson ranks 123rd in homers and 93rd in RBI among all hitters in MLB.
• Jackson Holliday's 17 home runs are a team-high total.
• Holliday ranks 110th in home runs and 141st in RBI among all MLB hitters this year.
• Jordan Westburg is batting .264 with 10 doubles, a triple, 15 home runs and 17 walks.
• Adley Rutschman has 16 doubles, a triple, nine home runs and 38 walks while batting .222.

Orioles Team Props

Rays vs. Orioles Highlights | MLB on FOX

Enjoy the best moments between the Tampa Bay Rays and the Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Baltimore Orioles

Tampa Bay Rays