Padres vs. Giants Prediction, Odds, Picks - August 19

Kai-Wei Teng will take the mound for the San Francisco Giants aiming to slow down Ramon Laureano and the San Diego Padres on Tuesday at 9:40 p.m. ET. The Padres are -211 moneyline favorites for this matchup against the Giants (+173). San Diego is favored on the run line (-1.5). The game's over/under is set at 8 runs.

Take a look at everything you need from a betting perspective on the Padres-Giants game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Rays vs. Giants Highlights | MLB on FOX

Check out the best moments between the Tampa Bay Rays and San Francisco Giants.

Padres vs. Giants Game Information & Odds

• When: Tuesday, August 19, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: MLB Network, SDPA, and NBCS-BA

Padres vs. Giants Prediction

• Score Prediction: Padres 4, Giants 3
• Total Prediction: Under 8 runs
• Win Probabilities: Padres 56%, Giants 44%

Padres vs. Giants Betting Insights

• The Padres have been favorites in 67 games this season and won 40 (59.7%) of those contests.
• This season San Diego has won four of its seven games when favored by at least -211 on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Padres have a 67.8% chance to win.
• The Giants have been underdogs in 48 games this season and have come away with the win 23 times (47.9%) in those contests.
• Oddsmakers have given San Francisco the worst odds of winning it has seen this season with a +173 moneyline listed for this contest.
• The moneyline set for this matchup implies the Giants have a 36.6% chance of walking away with the win.

Padres Recent Betting Performance

• The Padres have a 3-2 record across the five games they were a moneyline favorite in their last 10 matchups.
• In their last 10 outings (all had set totals), the Padres combined with their opponents to go over the run total five times.
• The Padres have put together a 6-4-0 record against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Manny Machado is the Padres best power option, crushing 20 round-trippers this season in addition to accumulating 72 RBI, both team highs.
• Among all hitters in the majors, Machado ranks 45th in home runs and 24th in RBI.
• Fernando Tatis Jr. is batting .264 with 23 doubles, two triples, 17 home runs and 71 walks.
• Tatis is 70th in homers and 110th in RBI among all MLB batters this year.
• Luis Arraez leads the Padres with a team-high batting average of .291.
• Arraez will look to build on his three-game hitting in this game. In his last five games he is hitting .316 with three doubles, a walk and two RBIs.
• Xander Bogaerts has 28 doubles, 10 home runs and 47 walks while batting .263.

Padres Team Props

Giants Recent Betting Performance

• The Giants have played as underdogs in three of their past 10 games and have gone 1-2 in those contests.
• When it comes to hitting the over, the Giants and their opponents are 3-6-1 in their last 10 games with a total.
• The Giants have won four of their last 10 games against the spread.

Giants Recent Stats

Giants Player Insights

• Rafael Devers has managed a team-leading 24 home runs and has driven in 82 runs.
• Among all hitters in the big leagues, Devers' home run total is 25th and his RBI tally is 11th.
• Devers takes a hitting streak of seven games into this game. During his last 10 outings he is hitting .282 with a double, four home runs, four walks and four RBIs.
• Jung Hoo Lee is batting .260 with 28 doubles, 10 triples, six home runs and 39 walks.
• Lee is 246th in homers and 133rd in RBI among all hitters in the big leagues.
• Willy Adames is batting .222 with 18 doubles, two triples, 19 home runs and 57 walks.
• Heliot Ramos leads the team in batting average with a high-water mark of .267.

Giants Team Props

Rays vs. Giants Highlights | MLB on FOX

Check out the best moments between the Tampa Bay Rays and San Francisco Giants.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

San Diego Padres

San Francisco Giants