Padres vs. Cardinals Prediction, Odds, Picks - August 3

Fernando Tatis Jr. and Brendan Donovan will be among the stars on display when the San Diego Padres face the St. Louis Cardinals on Sunday at 4:10 p.m. ET, at PETCO Park. The favored Padres have -155 moneyline odds against the underdog Cardinals, who are listed at +130. San Diego is a 1.5-run favorite (at +136 odds). The over/under is 8.5 runs for the contest.

Check out everything you need from a betting perspective on the Padres-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Cardinals Game Information & Odds

• When: Sunday, August 3, 2025 at 4:10 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and FDSMW

Padres vs. Cardinals Prediction

• Score Prediction: Padres 5, Cardinals 4
• Total Prediction: Under 8.5 runs
• Win Probabilities: Padres 55%, Cardinals 45%

Padres vs. Cardinals Betting Insights

• This season, the Padres have been favored 58 times and won 34, or 58.6%, of those games.
• San Diego is 15-10 this season when entering a game favored by -155 or more on the moneyline.
• The implied probability of a win from the Padres, based on the moneyline, is 60.8%.
• The Cardinals have been chosen as underdogs in 57 games this year and have walked away with the win 28 times (49.1%) in those games.
• This year, St. Louis has won six of 19 games when listed as at least +130 or worse on the moneyline.
• The moneyline set for this matchup implies the Cardinals have a 43.5% chance of walking away with the win.

Padres Recent Betting Performance

• The Padres went 3-3 across the six games they were a moneyline favorite in their last 10 matchups.
• In their last 10 outings -- all had a set run total -- the Padres and their opponents combined to go over the total four times.
• The Padres have a 5-5-0 record against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Manny Machado is the bat to watch in the Padres lineup, leading the team in batting average (.301), home runs (20), and RBI (72).
• Among all hitters in baseball, Machado is 26th in home runs and 13th in RBI.
• Machado carries a 10-game hitting streak into this matchup. During his last 10 outings he is hitting .476 with four doubles, two home runs and 12 RBIs.
• Tatis is hitting .264 with 18 doubles, two triples, 17 home runs and 61 walks.
• Tatis is 55th in homers and 108th in RBI on the year.
• Luis Arraez is hitting .299 with 21 doubles, four triples, six home runs and 22 walks.
• Arraez is on a 15-game hitting streak entering this contest. In his last 10 outings he is hitting .425 with three doubles, a home run, three walks and four RBIs.
• Xander Bogaerts is batting .269 with 24 doubles, seven home runs and 44 walks.
• Bogaerts has recorded at least one hit in three straight games. During his last five outings he is hitting .333 with a double, a walk and an RBI.

Padres Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in three of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Cardinals and their opponents have combined to hit the over three times.
• The Cardinals are 4-6-0 ATS over their last 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Donovan has 24 doubles, nine home runs and 39 walks while hitting .281.
• Among all batters in the big leagues, Donovan is 156th in home runs and 130th in RBI.
• Alec Burleson has a club-high .284 batting average.
• Burleson ranks 89th in home runs and 82nd in RBI among all hitters in MLB.
• Willson Contreras has been solid source of run production for the Cardinals with 15 long balls and 63 runs batted in.
• Masyn Winn is hitting .273 with 24 doubles, seven home runs and 27 walks.

Cardinals Team Props

Cardinals vs. Padres Highlights | MLB on FOX

Check out the best moments between the St. Louis Cardinals and San Diego Padres.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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