Iowa State vs. BYU Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 3:04 p.m. ET

FOX Sports

Oddsmakers project a close game between Big 12 foes when the Iowa State Cyclones (5-2) host the No. 11 BYU Cougars (7-0) on Saturday, October 25, 2025 at Jack Trice Stadium. BYU is a 2.5-point underdogs. This game has an over/under of 49.5 points.

The Cyclones' last game was against the Colorado Buffaloes, and they lost by a score of 24-17. The Cougars' most recent game was against the Utah Utes, and they won by a score of 24-21.

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Iowa State vs. BYU Game Information & Odds

When: Saturday, October 25, 2025 at 3:30 p.m. ET
Location: Jack Trice Stadium in Ames, Iowa
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Iowa State vs BYU Betting Information updated as of October 25, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Iowa State	-2.5 (-117)	-147	+123	49.5	-105	-121

Iowa State vs. BYU Prediction

Pick ATS: BYU (+2.5)
Pick OU: Under (49.5)
Prediction: BYU 25, Iowa State 22

Predictions are made by the Data Skrive betting model.

Learn more about the Iowa State Cyclones vs. the BYU Cougars game on FOX Sports!

Iowa State vs. BYU Betting Insights

Per the spread and over/under, the implied score for the matchup is Cyclones 26, Cougars 24.
The Cyclones have a 59.5% chance to win this meeting per the moneyline's implied probability. The Cougars hold a 44.8% implied probability.
Iowa State has covered three times in seven chances against the spread this season.
BYU is 5-2-0 ATS this season.

Iowa State vs. BYU: 2025 Stats Comparison

	Iowa State	BYU
Off. Points per Game (Rank)	29.3 (64)	35.6 (29)
Def. Points per Game (Rank)	19 (30)	15.6 (14)
Turnovers Allowed (Rank)	6 (21)	6 (21)
Turnovers Forced (Rank)	9 (56)	12 (22)

Iowa State 2025 Key Players

Name	Position	Stats
Rocco Becht	QB	1,622 YDS (63.2%) / 9 TD / 3 INT 86 RUSH YDS / 7 RUSH TD / 12.3 RUSH YPG
Abu Sama III	RB	481 YDS / 4 TD / 68.7 YPG / 5.2 YPC
Carson Hansen	RB	348 YDS / 2 TD / 58 YPG / 4.4 YPC 11 REC / 88 REC YDS / 0 REC TD / 14.7 REC YPG
Brett Eskildsen	WR	20 REC / 334 YDS / 2 TD / 47.7 YPG
Marcus Neal	DB	41 TKL / 5 TFL / 1 SACK
Jamison Patton	DB	31 TKL / 1 TFL / 2 INT / 2 PD
Kooper Ebel	LB	29 TKL / 1 TFL / 1 SACK
Ta'Shawn James	DB	27 TKL / 0 TFL

BYU 2025 Key Players

Name	Position	Stats
Bear Bachmeier	QB	1,386 YDS (62.7%) / 9 TD / 3 INT 359 RUSH YDS / 8 RUSH TD / 51.3 RUSH YPG
LJ Martin	RB	774 YDS / 4 TD / 110.6 YPG / 6.1 YPC 11 REC / 82 REC YDS / 0 REC TD / 13.7 REC YPG
Chase Roberts	WR	24 REC / 463 YDS / 4 TD / 66.1 YPG
Parker Kingston	WR	27 REC / 383 YDS / 2 TD / 54.7 YPG
Faletau Satuala	DB	38 TKL / 5 TFL / 1 SACK / 1 INT
Jack Kelly	LB	19 TKL / 5 TFL / 5 SACK
Isaiah Glasker	LB	22 TKL / 4 TFL / 2 SACK / 2 INT
Tanner Wall	DB	25 TKL / 1 TFL / 2 INT / 2 PD