Spurs midfielder Scott Parker (knee) remains a doubt for the hosts.
Centre-half Ledley King (hamstring) is also not match fit.
Defender William Gallas and midfielder Sandro remain out with calf strains.
Seamus Coleman is Everton's latest injury doubt ahead of the trip to London.
The Irishman limped out of the FA Cup victory over Tamworth to join the growing ranks of injured players.
Phil Jagielka (knee), Leon Osman (foot), Jack Rodwell (hamstring), Tony Hibbert (groin), Tim Cahill (groin) and Ross Barkley (knee) were absent on Saturday and all six are likely to be missing again.
Tottenham (from): Friedel, Assou-Ekotto, Kaboul, Walker, Bassong, Bale, Modric, Van der Vaart, Livermore, Kranjcar, Adebayor, Defoe, Rose, Dos Santos, Cudicini, Pavlyuchenko, Lennon, Pienaar, Dawson.
Everton (from): Howard, Neville, Heitinga, Distin, Baines, Bilyaletdinov, Fellaini, Drenthe, Donovan, Saha, Gueye, Hahnemann, Duffy, McFadden, McAleny, Vellios, Stracqualursi.