Unam Pumas maintained the last unbeaten record in Mexico's Clausura with a 1-0 victory at Morelia.
Juan Palencia's 57th-minute goal decided the contest and lifted Pumas six points clear at the top of Group Three.
Club America slipped to a fourth defeat in 10 games, 2-0 at home to Cruz Azul. Emanuel Villa scored in the 16th and 19th minutes as Cruz joined Morelia on 18 points.
A strong start provided the foundations for Toluca's 3-1 defeat of Santos Laguna.
There was no looking back for the home side after Jaime Ayovi and Diego Novaretti put it 2-0 up inside five minutes.
Although Oribe Peralta pulled a goal back in the 36th minute, substitute Emmanuel Cerda made the points safe for Toluca a minute from time, moving it to within a point of Club America at the head of Group Two.
