Sir Alex Ferguson will take a check on a trio of minor knocks before finalising his line-up.
Chris Smalling and Phil Jones have taken time to get over problems they sustained in a collision during last Sunday's FA Cup win over Manchester City, while Anderson took a blow in training this week.
Ferguson must also decide whether Paul Scholes is fit enough to take a starting berth after his shock retirement U-turn last weekend.
Bolton manager Owen Coyle is ready to play Gary Cahill after his proposed move to Chelsea was not completed in time.
Zat Knight will be on the bench as Cahill returns to the side and partners David Wheater in central defence.
Coyle will make a late check on goalkeeper Jussi Jaaskelainen, who is nearing full fitness after a thigh strain.
Man Utd (from): De Gea, Lindegaard, Amos, Rafael, Ferdinand, Evra, Jones, Smalling, Fryers, Cole, Carrick, Valencia, Park, Scholes, Anderson, Nani, Giggs, Rooney, Welbeck, Berbatov, Hernandez, Diouf, Keane.
Bolton (from): Jaaskelainen, Bogdan, Wheater, Cahill, Boyata, Knight, Eagles, Robinson, Muamba, Petrov, K Davies, Klasnic, Tuncay, M Davies, Pratley, Ngog, Blake, Reo-Coker, Steinsson, Ricketts, Riley, O'Halloran, Lynch.