Lyon routs Angers 6-0 to continue Sylvinho's winning start
Houssem Aouar opened the scoring from outside the penalty area in the 11th minute, Dembelé scored in the 37th after cutting inside a defender, and Depay grabbed his first before the break.
The Dutch forward scored his second after beating the offside trap, Dembelé made it 5-0 in the 65th, and Brazilian midfielder Jean Lucas came on as a substitute to complete the scoring in the 72nd.
Lyon, which lost several top players in the offseason including World Cup winner Nabil Fekir, Tanguy Ndombele, and Ferland Mendy, has a new coaching setup in Sylvinho and sporting director Juninho.
The side opened its league account with a 3-0 win over Monaco last week.