Escobar's three-run homer in the first started the night against Cleveland starter Carlos Carrasco (6-4). Escobar added a solo shot, his 10th of the season, in the seventh as Minnesota snapped a three-game losing streak.
The infielder has four multi-homer games in his career and two this season. Escobar, 5-foot-10 and 185 pounds, broke out last season with 21 home runs for the Twins.
Edwin Encarnacion homered for the Indians, who had their season-high six game-winning streak snapped.
Berrios (6-5) allowed four runs and five hits with a walk and seven strikeouts. It wasn't the type of sharp outing he had in his previous three starts when he gave up five runs total over 22 2/3 innings and pitched into the eighth inning each time.
Fernando Rodney secured his 12th save in 15 chances, which includes nine straight.
Carrasco had his second-shortest outing of the season with 3 2/3 innings. Miguel Sano's RBI double chased Carrrasco after the right-hander tied a season high with six runs on seven hits and three walks.
Encarnacion hit a two-run homer to the second deck in left field in the sixth, but the Twins kept adding to their early lead.
INDIANS MOVES
Cleveland activated outfielder Bradley Zimmer off the disabled list before the game and officially optioned Thursday's starter, pitcher Shane Bieber, to Triple-A Columbus. Zimmer was on the DL since May 12 with a rib contusion.
Zimmer was out of the starting lineup Friday with manager Terry Francona giving rookie Greg Allen another start for his work while Zimmer was out. Zimmer has hit .224 this season with two home runs and nine RBIs in 32 games.
TRAINER'S ROOM
Indians: OF Tyler Naquin (left hamstring strain) had a full workout at Double-A Akron on Friday and Francona said he'll likely be ready to play this weekend.
Twins: Manager Paul Molitor said the team is going to "be a little bit smarter today" about 1B Joe Mauer's workouts as he tries to recover from concussion syptoms. Mauer had trouble when working out before Thursday's game, but Molitor said he was able to stay at the park and for the entirety of the game. Mauer was also in the dugout on Friday.
UP NEXT
Indians: RHP Trevor Bauer (4-3, 2.61) is scheduled to start Saturday's matinee. Bauer will be making the start on extended five days rest after throwing a career-high 127 pitches on May 27 against Houston.
Twins: RHP Lance Lynn (3-4, 5.94) counters for Minnesota. Lynn has won his last two starts while allowing two runs in 12 2/3 innings.
