Dwight Lewis scored 16 of his 22 points in the first half, Mike Gerrity added six key points in the closing minutes and Southern California held off a furious rally by Washington in the final 10 minutes for a 67-64 win on Thursday night.
The Trojans (16-9, 8-5 Pac-10) handed Washington just its second home loss of the season and more importantly likely ended the Huskies (17-9, 7-7) hopes of repeating as Pac-10 regular season champs.
Down by 16 with nine minutes left, Washington suddenly awakened, closing within 61-60 on Venoy Overton's driving basket with 1:25 left.
But Gerrity answered with a layup of his own, then clinched the victory with a fallaway 12-footer with 15 seconds left. Gerrity finished with 12 points, all in the second half.
Quincy Pondexter led Washington with 18 points, but the Huskies NCAA tournament aspirations took a serious hit with the loss.