Papa Dia had a career-high 31 points while Robert Nyakundi and Derek Williams added 18 points each as SMU defeated Houston 94-83 on Saturday night.
Mouhammad Faye had 11 points and 10 rebounds for the Mustangs (14-14, 7-7 overall), who beat Houston for the first time in eight games since joining C-USA in 2005-06.
Aubrey Coleman had 30 points and nine rebounds for the Cougars (14-14, 6-8), and Adam Brown added 17 points.
Dia had 12 rebounds for his eighth double-double this season.
SMU, which trailed 39-33 at halftime, was on fire in the second half, shooting 66.7 percent (16 of 24) with nine 3-pointers. Houston helped by getting whistled for 15 fouls - the Mustangs shot 23 free throws after intermission, making 20.