Santos-Silva shot 9 for 12 from the floor.
De'Riante Jenkins had 14 points for VCU (20-6, 11-2 Atlantic 10 Conference). Marcus Evans added nine assists.
Rhode Island totaled 20 points in the second half, a season low for the team.
VCU leveled the season series against Rhode Island with the win. Rhode Island defeated VCU 71-65 on Jan. 23. VCU matches up against George Washington at home on Saturday. Rhode Island plays Davidson at home on Friday.