Antonio Woods added 16 points for Penn (3-0) and AJ Brodeur chipped in with 10 points, five rebounds and four assists. Reserve Jarrod Simmons had 11 points for the Quakers, who made 35 of 61 shots, including 13 of 29 (45 percent) from 3-point range, and had 12 different players score.
Kyle Stout paced the Leopards (1-2) with 13 points and four assists, while Dylan Hastings came off the bench to score 11 with three blocked shots. Lafayette trailed 44-27 at halftime and trailed by 30 after Woods' 3-pointer with 14:14 left to play.
The Leopards made half of their 52 shots from the floor, including 8 of 20 (40 percent) from distance, but turned the ball over 18 times.