Jalen Pickett made two free throws with 10 seconds left for a 51-47 lead. Nehemiah Mack scored for Manhattan with four seconds left. Pickett was fouled again and missed the front end of a one-and-one with 3.9 seconds left, but Mack's half-court heave hit the backboard.
Kadeem Smithen had nine rebounds for Siena (12-12, 7-4 Metro Atlantic Athletic Conference).
The Saints improve to 2-0 against the Jaspers on the season. Siena defeated Manhattan 53-40 on Jan. 26. Siena plays Rider on the road on Sunday. Manhattan matches up against Niagara on the road next Friday.