Eagles vs. Rams 2025 Prediction, Odds, Picks - Sep 21

The Philadelphia Eagles (2-0) are favored by 3.5 points against the Los Angeles Rams (2-0) on September 21, 2025, starting at 1 p.m. ET, airing on FOX. The expected point total for the game is 45.5.

Keep up with the 2025 NFL season on FOX Sports.

Julian Edelman inducted into Patriots HOF, should the tush push be banned? & more Week 3 Storylines

The 'FOX NFL Kickoff' crew discussed their Week 3 storylines, including Julian Edelman's induction into the New England Patriots' Hall of Fame, whether the tush push should be banner & more.

Eagles vs. Rams Odds & Betting Lines

Eagles vs. Rams Prediction & Pick

• Pick ATS: Eagles (-3.5)
  
• Pick OU: Under (45.5)
  
• Prediction: Eagles 28 - Rams 16

How to Watch Philadelphia vs. Los Angeles

• Game date: Sunday, September 21, 2025
• Time: 1 p.m. ET
• Venue: Lincoln Financial Field
• Location: Philadelphia, Pennsylvania
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Eagles vs. Rams Recent Matchups

• In their past five head-to-head contests, Philadelphia has defeated Los Angeles five times.
• Over their last five head-to-head matchups, Philadelphia has racked up 161 points, while Los Angeles has compiled 114.

Philadelphia Betting Info

• Philadelphia has one win against the spread in two games this year.
• The Eagles have not covered the spread when favored by 3.5 points or more this season (in one opportunity).
• Philadelphia games this year have not gone over the total in two opportunities.
• The Eagles have been moneyline favorites two other times this season, and they won both.
• The implied probability in this matchup, considering the moneyline, gives the Eagles a 66.4% chance to win.

Eagles Stats

Philadelphia's Key Players

Offense

• Jalen Hurts has passed for 253 yards, zero touchdowns and zero interceptions this year. He averages 126.5 yards per game and 5.6 per attempt, while completing 75.6% of his passes.
• He has also rushed for 77 yards (second on the Eagles) and added three touchdowns on the ground, while averaging 38.5 rushing yards per game.
• Saquon Barkley's rushing statline this season includes 148 yards (ninth in the NFL) and two TDs. He's averaging 74.0 yards per game and 3.7 per attempt (27th in the NFL).
• He's caught six passes (on seven targets) for 30 receiving yards with zero touchdowns. He's averaging 15.0 receiving yards and 3.0 catches per game.
• Through two games played, DeVonta Smith is averaging 34.5 yards and 3.5 receptions per game on the way to 69 receiving yards and seven catches. He's been targeted nine times, but has not caught a touchdown pass.
• Jahan Dotson has 63 receiving yards without a touchdown with four catches on four targets. He is averaging 2.0 receptions and 31.5 yards per game.

Defense

• On defense for the Eagles, Andrew Mukuba has racked up 10 tackles, 1.0 TFL, 0.5 sacks, and one interception in 2025.
• Zack Baun has 15 tackles and 1.0 TFL this season. His tackle total leads the Eagles.
• This season, Jihaad Campbell has put up 10 tackles.
• Jordan Davis has 1.0 TFL and 11 tackles on the year.

Los Angeles Betting Info

• Los Angeles has covered the spread in a game two times this season (2-0-0).
• Los Angeles games have gone over the total once this season.
• The Rams will play as the underdog for the first time this season.
• The bookmakers' moneyline implies a 37.9% chance of a victory for the Rams.

Rams Stats

Los Angeles' Key Players

Offense

• Puka Nacua has totaled 221 receiving yards (fourth in the NFL) on 18 receptions (first in the NFL), while being targeted 20 times this season.
• In two games, Matthew Stafford has 543 passing yards (eighth-best in the NFL), with three touchdowns against one interception and completing 71.0% of his attempts.
• This season, Davante Adams has caught 10 passes for 157 receiving yards with one touchdown in the passing game. He has been targeted 21 total times and is averaging 5.0 receptions per game in two games played.
• Kyren Williams puts up 66.0 rushing yards per game through two games (132 total yards), with one rushing touchdown.

Defense

• Byron Young's 2025 showing includes 14 tackles, 3.0 TFL, and three sacks in two games. He is third on the Rams in tackles.
• Nathan Landman's stat sheet includes 18 tackles.
• In the 2025 campaign, Kamren Curl has 17 tackles, 2.0 TFL, and one sack through two games.
• Kamren Kinchens has 14 tackles and one pass defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Philadelphia Eagles

Los Angeles Rams