2025-26 Buffalo Bills Odds: Odds to win Super Bowl, NFL Playoffs, Division

Updated Dec. 31, 2025 6:30 p.m. ET

Data Skrive

At the moment the Buffalo Bills are seventh in the NFL in terms of odds to win the Super Bowl, listed at +1100.

In their most recent game, the Bills lost 13-12 to the Philadelphia Eagles. Josh Allen had 262 yards on 23-of-35 passing (65.7%), with no touchdowns and no interceptions. He also carried the ball seven times for 27 yards and two rushing touchdowns. James Cook took 20 carries for 74 yards (3.7 yards per carry), while adding one reception for three yards in the passing game. Brandin Cooks hauled in four receptions for 101 yards (averaging 25.3 per catch).

Bills Postseason Odds

Odds to win the Super Bowl: +1100 (Bet $100 to win $1,100)

Learn more about the Buffalo Bills on Fox Sports.

Bills Super Bowl Odds Insights

In terms of winning the Super Bowl, the Bills (+1100) rank better according to oddsmakers (seventh-best in NFL) than they do in our computer rankings (eighth-best).
Before the season, the Bills had +650 odds to win the Super Bowl. Those odds have since worsened to +1100, which is the fifth-smallest change among all teams.
With Super Bowl odds of +1100, the Bills sport an 8.3% chance of being Super Bowl champions.

Bills Betting Insights

The Bills have won seven games against the spread this season, while failing to cover nine times.
A total of eight out of 16 Buffalo games this season have gone over the point total.
The Bills have been the moneyline favorite 14 total times this season. They've finished 9-5 in those games.
Buffalo has won both games it has played as underdogs this season.

Bills Top Players

This year Allen has put up 3,668 passing yards (229.3 YPG) while completing 69.3% of his passes, with 25 touchdowns and 10 interceptions. He also has 579 rushing yards on 112 attempts (plus 14 scores), averaging 36.2 yards per game.
Allen's game status for Sunday's Week 18 matchup against the Jets is unknown. He was a non-participant in the Bills' last practice.
Cook has 307 carries for a team-best 1,606 rushing yards (100.4 per game) and 12 touchdowns. He also has 33 catches for 291 receiving yards (18.2 per game) and two touchdowns.
Khalil Shakir has hauled in 72 passes for a team best 719 yards plus four touchdowns. He averages 44.9 receiving yards per game.
Dalton Kincaid has also contributed with 523 yards, on 36 catches plus five touchdowns. He puts up 47.5 receiving yards per game.
Kincaid's game status for Sunday's Week 18 matchup against the Jets is unknown. He was a limited participant in the Bills' last practice.
Dawson Knox has caught 34 passes on 47 targets for 393 yards and three touchdowns.
Knox's game status for Sunday's Week 18 matchup against the Jets is currently unknown. He was a limited participant in the Bills' last practice.
Greg Rousseau has notched a team-leading 7.0 sacks, while adding 6.0 TFL and 46 tackles.
Cole Bishop's 85 tackles, 4.0 TFL, two sacks, and three interceptions make him the team leader for tackles and interceptions.

Bills 2025-26 Schedule

Opponent	Week	Date	Opponent Power Ranking	Favorite	Total
Ravens	1	Sept. 7	12th	Ravens (-2.5)	50.5
@ Jets	2	Sept. 14	31st	Bills (-6.5)	47.5
Dolphins	3	Sept. 18	26th	Bills (-12.5)	50.5
Saints	4	Sept. 28	22nd	Bills (-14.5)	48.5
Patriots	5	Oct. 5	6th	Bills (-7.5)	50.5
@ Falcons	6	Oct. 13	19th	Bills (-4.5)	50.5
@ Panthers	8	Oct. 26	21st	Bills (-7.5)	47.5
Chiefs	9	Nov. 2	20th	Chiefs (-1.5)	53.5
@ Dolphins	10	Nov. 9	26th	Bills (-7.5)	50.5
Buccaneers	11	Nov. 16	18th	Bills (-6.5)	46.5
@ Texans	12	Nov. 20	3rd	Bills (-5.5)	44.5
@ Steelers	13	Nov. 30	16th	Bills (-3)	44.5
Bengals	14	Dec. 7	23rd	Bills (-6.5)	54.5
@ Patriots	15	Dec. 14	6th	Bills (-2.5)	49.5
@ Browns	16	Dec. 21	30th	Bills (-10.5)	41.5
Eagles	17	Dec. 28	7th	Bills (-3)	45.5
Jets	18	Jan. 4	31st	Bills (-7.5)	38.5