2025-26 Buffalo Bills Odds: Odds to win Super Bowl, NFL Playoffs, Division

Updated Jan. 16, 2026 7:31 p.m. ET

Data Skrive

As of Jan. 16, the Buffalo Bills' odds of winning the Super Bowl (+650) make them fourth-best in the NFL.

In their last outing, the Bills won 27-24 over the Jacksonville Jaguars. Josh Allen threw for 273 yards, with one touchdown and no interceptions on 28-of-35 passing (80.0%). He also added 11 carries for 33 yards and two rushing touchdowns. James Cook totaled 46 rushing yards on 15 carries (3.1 yards per carry). He also had two catches for five yards. Khalil Shakir recorded 12 receptions for 82 yards (averaging 6.8 per catch).

Bills Postseason Odds

Odds to win the Super Bowl: +650 (Bet $100 to win $650)

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Bills Super Bowl Odds Insights

The Bills carry +650 odds to win the Super Bowl, which ranks fourth-best in the NFL. Our computer rankings have them ranked seventh-best, a difference of three spots.
According to oddsmakers, the Bills are currently +650 to win the Super Bowl. Those odds are the same as the +650 odds they began the season with.
At +650, the Bills have a 13.3% chance of winning the Super Bowl.

Bills Betting Insights

The Bills have covered eight times in 17 chances against the spread this season.
In Buffalo's 17 games this season, the combined scoring has gone over the point total nine times.
The Bills have won 66.7% of the games this season when they were favored on the moneyline (10-5).
Buffalo has won both games it has played as underdogs this season.

Bills Top Players

Allen has 3,668 passing yards (229.3 YPG) and a 69.3% completion percentage (319-for-460) while pitching 25 touchdowns and 10 interceptions. He also has 579 rushing yards on 112 attempts (plus 14 touchdowns), averaging 36.2 yards per game.
Allen's game status for Saturday's Divisional matchup against the Broncos is unknown. He was a full participant in the Bills' last practice.
Cook has taken 309 carries for a team-leading 1,621 rushing yards (95.4 YPG) and 12 touchdowns. He's also caught 33 passes for 291 yards with two touchdowns through the air.
Shakir has 72 catches (on 95 targets) and leads the team with 719 receiving yards (44.9 per game) while hauling in four touchdowns.
Dalton Kincaid has 39 catches for 571 yards (47.6 per game) and five touchdowns.
Kincaid's game status for Saturday's Divisional matchup against the Broncos is unknown. He was a limited participant in the Bills' last practice.
Dawson Knox has collected 417 yards on 36 receptions with four touchdowns, averaging 26.1 yards per game.
This season Greg Rousseau leads the team with 7.0 sacks and has added 6.0 TFL and 46 tackles.
Rousseau's status for Saturday is unknown. He was a limited participant in the Bills' most recent practice.
Cole Bishop leads the team in both tackles and interceptions, totaling 85 tackles, 4.0 TFL, two sacks, and three interceptions over the current campaign.

Bills 2025-26 Schedule

Opponent	Week	Date	Opponent Power Ranking	Favorite	Total
Ravens	1	Sept. 7	13th	Ravens (-2.5)	50.5
@ Jets	2	Sept. 14	32nd	Bills (-6.5)	47.5
Dolphins	3	Sept. 18	26th	Bills (-12.5)	50.5
Saints	4	Sept. 28	22nd	Bills (-14.5)	48.5
Patriots	5	Oct. 5	6th	Bills (-7.5)	50.5
@ Falcons	6	Oct. 13	19th	Bills (-4.5)	50.5
@ Panthers	8	Oct. 26	20th	Bills (-7.5)	47.5
Chiefs	9	Nov. 2	21st	Chiefs (-1.5)	53.5
@ Dolphins	10	Nov. 9	26th	Bills (-7.5)	50.5
Buccaneers	11	Nov. 16	18th	Bills (-6.5)	46.5
@ Texans	12	Nov. 20	3rd	Bills (-5.5)	44.5
@ Steelers	13	Nov. 30	17th	Bills (-3)	44.5
Bengals	14	Dec. 7	24th	Bills (-6.5)	54.5
@ Patriots	15	Dec. 14	6th	Bills (-2.5)	49.5
@ Browns	16	Dec. 21	29th	Bills (-10.5)	41.5
Eagles	17	Dec. 28	9th	Bills (-3)	45.5
Jets	18	Jan. 4	32nd	Bills (-12.5)	39.5
@ Jaguars	WC	Jan. 11	4th	Jaguars (-1.5)	51.5
@ Broncos	Div. Round	Jan. 17	8th	Bills (-11.5)	41.5