2025-26 Buffalo Bills Odds: Odds to win Super Bowl, NFL Playoffs, Division

Updated Jan. 13, 2026 10:31 p.m. ET

Data Skrive

The Buffalo Bills have +650 odds to win the Super Bowl, fourth-best in the NFL as of Jan. 13.

The Bills defeated the Jacksonville Jaguars 27-24 in their last outing. Josh Allen had 273 yards on 28-of-35 passing (80.0%) for the Bills, with one touchdown and no interceptions. He also added 11 carries for 33 yards and two rushing touchdowns. James Cook totaled 46 rushing yards on 15 carries (3.1 yards per carry). He also had two catches for five yards. Khalil Shakir recorded 12 receptions for 82 yards (averaging 6.8 per catch).

Bills Postseason Odds

Odds to win the Super Bowl: +650 (Bet $100 to win $650)

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Bills Super Bowl Odds Insights

The Bills' Super Bowl odds (+650) rank them fourth-best in the NFL, three spots better compared to our computer rankings, where they are seventh-best.
The Bills' updated Super Bowl odds, according to bookmakers, are +650, which are the same odds as they had during the preseason (+650).
With Super Bowl odds of +650, the Bills have a 13.3% chance of being Super Bowl champions.

Bills Betting Insights

The Bills have covered eight times in 17 games with a spread this season.
A total of nine out of 17 Buffalo games this season have gone over the point total.
The Bills are 10-5 in games they were listed as the moneyline favorite (winning 66.7% of those games).
Buffalo has won both games it has played as underdogs this season.

Bills Top Players

Allen has 3,668 passing yards (229.3 per game) and a 69.3% completion percentage (319-for-460) while firing 25 touchdowns and 10 interceptions. He also has 579 rushing yards on 112 carries (plus 14 touchdowns), averaging 36.2 yards per game.
Allen's game status for Saturday's Divisional matchup against the Broncos is unknown. He was a limited participant in the Bills' last practice.
Cook has taken 309 carries for a team-leading 1,621 rushing yards (95.4 YPG) and 12 touchdowns. He's also caught 33 passes for 291 yards with two touchdowns through the air.
Shakir has 72 catches (95 targets) and paces his team with 719 receiving yards (44.9 ypg) and four touchdowns.
Dalton Kincaid has 39 catches for 571 yards (47.6 per game) and five touchdowns.
Kincaid's status for Saturday is currently unknown. He was a limited participant in the Bills' most recent practice.
Dawson Knox has collected 417 yards on 36 receptions with four touchdowns, averaging 26.1 yards per game.
Greg Rousseau has 7.0 sacks to lead the team, and has also racked up 6.0 TFL and 46 tackles.
Rousseau's game status for Saturday's Divisional matchup against the Broncos is unknown. He was a limited participant in the Bills' last practice.
Cole Bishop's 85 tackles, 4.0 TFL, two sacks, and three interceptions make him the team leader for tackles and interceptions.

Bills 2025-26 Schedule

Opponent	Week	Date	Opponent Power Ranking	Favorite	Total
Ravens	1	Sept. 7	13th	Ravens (-2.5)	50.5
@ Jets	2	Sept. 14	32nd	Bills (-6.5)	47.5
Dolphins	3	Sept. 18	26th	Bills (-12.5)	50.5
Saints	4	Sept. 28	22nd	Bills (-14.5)	48.5
Patriots	5	Oct. 5	6th	Bills (-7.5)	50.5
@ Falcons	6	Oct. 13	19th	Bills (-4.5)	50.5
@ Panthers	8	Oct. 26	20th	Bills (-7.5)	47.5
Chiefs	9	Nov. 2	21st	Chiefs (-1.5)	53.5
@ Dolphins	10	Nov. 9	26th	Bills (-7.5)	50.5
Buccaneers	11	Nov. 16	18th	Bills (-6.5)	46.5
@ Texans	12	Nov. 20	3rd	Bills (-5.5)	44.5
@ Steelers	13	Nov. 30	17th	Bills (-3)	44.5
Bengals	14	Dec. 7	24th	Bills (-6.5)	54.5
@ Patriots	15	Dec. 14	6th	Bills (-2.5)	49.5
@ Browns	16	Dec. 21	29th	Bills (-10.5)	41.5
Eagles	17	Dec. 28	9th	Bills (-3)	45.5
Jets	18	Jan. 4	32nd	Bills (-12.5)	39.5
@ Jaguars	WC	Jan. 11	4th	Jaguars (-1.5)	51.5
@ Broncos	Div. Round	Jan. 17	8th	Broncos (-1.5)	46.5