2025-26 Buffalo Bills Odds: Odds to win Super Bowl, NFL Playoffs, Division

Updated Jan. 16, 2026 9:31 a.m. ET

Data Skrive

The Buffalo Bills right now have the fourth-best odds to win the Super Bowl in the entire NFL at +650.

In their last outing on Jan. 11, the Bills took home a 27-24 win against the Jacksonville Jaguars. Josh Allen led the Bills with 273 yards on 28-of-35 passing (80.0%) for one touchdown and no interceptions. He also carried the ball 11 times for 33 yards and two rushing touchdowns. James Cook ran for 46 yards on 15 carries (3.1 yards per carry), adding two receptions for five yards. Khalil Shakir had 82 yards on 12 catches (6.8 per reception) in that game.

Bills Postseason Odds

Odds to win the Super Bowl: +650 (Bet $100 to win $650)

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Bills Super Bowl Odds Insights

As far as winning the Super Bowl, the Bills (+650) rank higher according to oddsmakers (fourth-best in NFL) than they do in our computer rankings (seventh-best).
According to sportsbooks, the Bills are currently +650 to win the Super Bowl. Those odds are the same as the +650 odds they started the season with.
Based on their current odds (+650), the Bills sport a 13.3% chance of winning the Super Bowl.

Bills Betting Insights

The Bills have covered eight times in 17 matchups with a spread this season.
Buffalo and its opponent have combined to go over the point total nine out of 17 times this season.
The Bills have gone 10-5 in games they were listed as the moneyline favorite (winning 66.7% of those games).
Buffalo has won both games it has played as underdogs this season.

Bills Top Players

Allen has 3,668 passing yards (229.3 per game) and a 69.3% completion percentage (319-for-460) while tossing 25 touchdowns and 10 interceptions. He also has 579 yards on the ground on 112 attempts (plus 14 touchdowns), averaging 36.2 YPG.
Allen's game status for Saturday's Divisional matchup against the Broncos is currently unknown. He was a full participant in the Bills' last practice.
Cook has rushed for a team-best 1,621 yards (95.4 YPG) and 12 touchdowns. He also has 291 receiving yards on 33 catches and two touchdowns.
Shakir has 72 catches (on 95 targets) and leads the team with 719 receiving yards (44.9 per game) while scoring four touchdowns.
Dalton Kincaid has also chipped in with 39 receptions (on 49 targets) for 571 yards, scoring five touchdowns.
Kincaid's status for Saturday is currently unknown. He was a limited participant in the Bills' most recent practice.
Dawson Knox has racked up 417 yards on 36 receptions with four touchdowns, averaging 26.1 yards per game.
Greg Rousseau has 7.0 sacks to lead the team, and has also collected 6.0 TFL and 46 tackles.
Rousseau's game status for Saturday's Divisional matchup against the Broncos is unknown. He was a limited participant in the Bills' last practice.
Cole Bishop's 85 tackles, 4.0 TFL, two sacks, and three interceptions make him the team leader for tackles and interceptions.

Bills 2025-26 Schedule

Opponent	Week	Date	Opponent Power Ranking	Favorite	Total
Ravens	1	Sept. 7	13th	Ravens (-2.5)	50.5
@ Jets	2	Sept. 14	32nd	Bills (-6.5)	47.5
Dolphins	3	Sept. 18	26th	Bills (-12.5)	50.5
Saints	4	Sept. 28	22nd	Bills (-14.5)	48.5
Patriots	5	Oct. 5	6th	Bills (-7.5)	50.5
@ Falcons	6	Oct. 13	19th	Bills (-4.5)	50.5
@ Panthers	8	Oct. 26	20th	Bills (-7.5)	47.5
Chiefs	9	Nov. 2	21st	Chiefs (-1.5)	53.5
@ Dolphins	10	Nov. 9	26th	Bills (-7.5)	50.5
Buccaneers	11	Nov. 16	18th	Bills (-6.5)	46.5
@ Texans	12	Nov. 20	3rd	Bills (-5.5)	44.5
@ Steelers	13	Nov. 30	17th	Bills (-3)	44.5
Bengals	14	Dec. 7	24th	Bills (-6.5)	54.5
@ Patriots	15	Dec. 14	6th	Bills (-2.5)	49.5
@ Browns	16	Dec. 21	29th	Bills (-10.5)	41.5
Eagles	17	Dec. 28	9th	Bills (-3)	45.5
Jets	18	Jan. 4	32nd	Bills (-12.5)	39.5
@ Jaguars	WC	Jan. 11	4th	Jaguars (-1.5)	51.5
@ Broncos	Div. Round	Jan. 17	8th	Broncos (-1.5)	46.5