Red Sox vs. Cardinals Prediction, Odds, Picks - April 5

The Boston Red Sox and St. Louis Cardinals will play on Saturday at Fenway Park, at 4:10 p.m. ET, with Jarren Duran and Alec Burleson among those expected to step up at the plate. The Cardinals have been listed as +112 moneyline underdogs for this matchup against the Red Sox (-132). Boston is the favorite on the run line (-1.5). An 8.5-run over/under has been set in this game.

Here's everything you need from a betting perspective on the Red Sox-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Check out the top highlights between the St. Louis Cardinals and the Boston Red Sox.

Red Sox vs. Cardinals Game Information & Odds

• When: Saturday, April 5, 2025 at 4:10 p.m. ET
• Where: Fenway Park in Boston, Massachusetts
• How to watch on TV: NESN and FDSMW

Red Sox vs. Cardinals Prediction

• Score Prediction: Red Sox 5, Cardinals 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Red Sox 58%, Cardinals 42%

Red Sox vs. Cardinals Betting Insights

• The Red Sox have been favorites in four games this season and won three (75%) of those contests.
• Boston has not entered a game this season as bigger favorites on the moneyline than the -132 odds on them winning this game.
• Sportsbooks have implied with the moneyline set for this matchup that the Red Sox have a 56.9% chance to win.
• The Cardinals have been victorious in three of the four contests they have been chosen as underdogs in this season.
• St. Louis has yet to play a game this season with longer moneyline odds than +112.
• The moneyline set for this matchup implies the Cardinals have a 47.2% chance of coming away with a victory in the contest.

Red Sox Player Insights

• Wilyer Abreu's three long balls and eight RBI both lead the Red Sox, in addition to his team-high .500 average.
• In all of the majors, Abreu ranks 12th in home runs and 12th in RBI.
• Abreu brings a hitting streak of two games into this matchup. During his last five outings he is batting .385 with a double, a home run, five walks and three RBI.
• Kristian Campbell has four doubles, two home runs and six walks while hitting .423.
• Including all MLB batters, Campbell ranks 29th in home runs and 48th in RBI.
• Campbell carries a three-game streak with at least one hit into this matchup. During his last five outings he is batting .375 with three doubles, a home run, four walks and four RBI.
• Alex Bregman has three doubles, a home run and two walks while batting .314.
• Bregman will look to build on his seven-game hitting in this game. In his last eight outings he is hitting .314 with three doubles, a home run, two walks and four RBI.
• Trevor Story is hitting .250 with two home runs and a walk.

Red Sox Team Props

Cardinals Player Insights

• Ivan Herrera has managed a team-high four home runs and has driven in 11 runs.
• Among all hitters in the big leagues, Herrera's home run total ranks fourth and his RBI tally ranks second.
• Lars Nootbaar has a club-leading .414 batting average.
• Nootbaar is 29th in homers and 27th in RBI among all hitters in the big leagues.
• Nolan Arenado is hitting .357 with three doubles, a home run and five walks.
• Victor Scott II is hitting .308 with a double, a home run and three walks.

Cardinals Team Props

Cardinals vs. Red Sox Baseball | MLB on FOX

Check out the top highlights between the St. Louis Cardinals and the Boston Red Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Boston Red Sox

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