College Football Top 25 Week 6 2025 Predictions, Betting Odds & TV Schedule

There are 15 games on the college football schedule in Week 6 that feature a ranked team. That includes the No. 3 Miami (FL) Hurricanes versus the No. 18 Florida State Seminoles.

Searching for an edge in college football? We analyze the betting odds for all the important games below.

Check out the full college football schedule on FOX Sports! Or visit FOX Sports' college football hub for everything you need to make the most of this season’s action.

Week 6 Betting Lines & Game Info

No. 23 BYU Cougars vs. West Virginia Mountaineers

Odds & Prediction

• Spread: Cougars (-20.5)
• Moneyline: Cougars -1587, Mountaineers +900
• Total: 47.5 points
• Prediction: BYU 41, West Virginia 4

How to Watch

• Game Date: Friday, Oct. 3
• Game Time: 10:30 p.m. ET
• TV Channel: ESPN
• Location: Provo, Utah
• Box Score

No. 12 Georgia Bulldogs vs. Kentucky Wildcats

Odds & Prediction

• Spread: Bulldogs (-20.5)
• Moneyline: Bulldogs -1449, Wildcats +850
• Total: 49.5 points
• Prediction: Georgia 36, Kentucky 21

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 12 p.m. ET
• TV Channel: ABC
• Location: Athens, Georgia
• Box Score

Purdue Boilermakers vs. No. 22 Illinois Fighting Illini

Odds & Prediction

• Spread: Fighting Illini (-7.5)
• Moneyline: Fighting Illini -310, Boilermakers +250
• Total: 54.5 points
• Prediction: Illinois 36, Purdue 22

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 12 p.m. ET
• TV Channel: BTN
• Location: West Lafayette, Indiana
• Box Score

No. 20 Michigan Wolverines vs. Wisconsin Badgers

Odds & Prediction

• Spread: Wolverines (-16.5)
• Moneyline: Wolverines -800, Badgers +550
• Total: 42.5 points
• Prediction: Michigan 37, Wisconsin 9

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 12 p.m. ET
• TV Channel: FOX
• Location: Ann Arbor, Michigan
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Cincinnati Bearcats vs. No. 14 Iowa State Cyclones

Odds & Prediction

• Spread: Bearcats (-1.5)
• Moneyline: Bearcats -125, Cyclones +105
• Total: 55.5 points
• Prediction: Cincinnati 24, Iowa State 23

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 12 p.m. ET
• TV Channel: ESPN2
• Location: Cincinnati, Ohio
• Box Score

Louisville Cardinals vs. No. 24 Virginia Cavaliers

Odds & Prediction

• Spread: Cardinals (-6.5)
• Moneyline: Cardinals -250, Cavaliers +205
• Total: 60.5 points
• Prediction: Louisville 34, Virginia 27

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 3:30 p.m. ET
• TV Channel: ESPN2
• Location: Louisville, Kentucky
• Box Score

No. 10 Alabama Crimson Tide vs. No. 16 Vanderbilt Commodores

Odds & Prediction

• Spread: Crimson Tide (-13.5)
• Moneyline: Crimson Tide -500, Commodores +380
• Total: 57.5 points
• Prediction: Vanderbilt 32, Alabama 30

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 3:30 p.m. ET
• TV Channel: ABC
• Location: Tuscaloosa, Alabama
• Box Score

UCLA Bruins vs. No. 7 Penn State Nittany Lions

Odds & Prediction

• Spread: Nittany Lions (-24.5)
• Moneyline: Nittany Lions -2083, Bruins +1100
• Total: 48.5 points
• Prediction: Penn State 33, UCLA 14

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 3:30 p.m. ET
• TV Channel: CBS
• Location: Pasadena, California
• Box Score

No. 21 Notre Dame Fighting Irish vs. Boise State Broncos

Odds & Prediction

• Spread: Fighting Irish (-21.5)
• Moneyline: Fighting Irish -1587, Broncos +900
• Total: 63.5 points
• Prediction: Notre Dame 49, Boise State 18

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 3:30 p.m. ET
• TV Channel: NBC
• Location: South Bend, Indiana
• Box Score

Florida Gators vs. No. 9 Texas Longhorns

Odds & Prediction

• Spread: Longhorns (-5.5)
• Moneyline: Longhorns -205, Gators +170
• Total: 42.5 points
• Prediction: Texas 19, Florida 17

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 3:30 p.m. ET
• TV Channel: ESPN
• Location: Gainesville, Florida
• Box Score

No. 5 Oklahoma Sooners vs. Kent State Golden Flashes

Odds & Prediction

• Spread: Sooners (-45.5)
• Moneyline: Sooners , Golden Flashes
• Total: 53.5 points
• Prediction: Oklahoma 49, Kent State 7

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 4 p.m. ET
• TV Channel: SEC Network
• Location: Norman, Oklahoma
• Box Score

Houston Cougars vs. No. 11 Texas Tech Red Raiders

Odds & Prediction

• Spread: Red Raiders (-12.5)
• Moneyline: Red Raiders -521, Cougars +390
• Total: 51.5 points
• Prediction: Texas Tech 34, Houston 21

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 7 p.m. ET
• TV Channel: ESPN
• Location: Houston, Texas
• Box Score

No. 18 Florida State Seminoles vs. No. 3 Miami (FL) Hurricanes

Odds & Prediction

• Spread: Hurricanes (-3.5)
• Moneyline: Hurricanes -170, Seminoles +142
• Total: 54.5 points
• Prediction: Miami (FL) 30, Florida State 29

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 7:30 p.m. ET
• TV Channel: ABC
• Location: Tallahassee, Florida
• Box Score

No. 6 Texas A&M Aggies vs. Mississippi State Bulldogs

Odds & Prediction

• Spread: Aggies (-17.5)
• Moneyline: Aggies -901, Bulldogs +600
• Total: 57.5 points
• Prediction: Texas A&M 34, Mississippi State 23

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 7:30 p.m. ET
• TV Channel: SEC Network
• Location: College Station, Texas
• Box Score

No. 1 Ohio State Buckeyes vs. Minnesota Golden Gophers

Odds & Prediction

• Spread: Buckeyes (-23.5)
• Moneyline: Buckeyes -2778, Golden Gophers +1300
• Total: 43.5 points
• Prediction: Ohio State 33, Minnesota 5

How to Watch

• Game Date: Saturday, Oct. 4
• Game Time: 7:30 p.m. ET
• TV Channel: NBC
• Location: Columbus, Ohio
• Box Score

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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