College Football Top 25 Week 4 2025 Predictions, Betting Odds & TV Schedule

Top-25 teams will be in action in 16 games on the Week 4 college football slate. That includes the No. 9 Illinois Fighting Illini playing the No. 19 Indiana Hoosiers at Memorial Stadium (Bloomington, IN).

Here are the betting odds to analyze before Week 4 in college football.

Check out the full college football schedule on FOX Sports! Or visit FOX Sports' college football hub for everything you need to make the most of this season’s action.

Week 4 Betting Lines & Game Info

No. 16 Utah Utes vs. No. 17 Texas Tech Red Raiders

Odds & Prediction

• Spread: Utes (-3.5)
• Moneyline: Utes -175, Red Raiders +145
• Total: 58.5 points
• Prediction: Utah 30, Texas Tech 26

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 12 p.m. ET
• TV Channel: FOX
• Location: Salt Lake City, Utah
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

No. 15 Tennessee Volunteers vs. UAB Blazers

Odds & Prediction

• Spread: Volunteers (-39.5)
• Moneyline: Volunteers , Blazers
• Total: 69.5 points
• Prediction: Tennessee 41, UAB 28

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 12:45 p.m. ET
• TV Channel: SEC Network
• Location: Knoxville, Tennessee
• Box Score

No. 6 Oregon Ducks vs. Oregon State Beavers

Odds & Prediction

• Spread: Ducks (-34.5)
• Moneyline: Ducks , Beavers
• Total: 58.5 points
• Prediction: Oregon 37, Oregon State 22

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 3 p.m. ET
• TV Channel: BTN
• Location: Eugene, Oregon
• Box Score

No. 24 Notre Dame Fighting Irish vs. Purdue Boilermakers

Odds & Prediction

• Spread: Fighting Irish (-24.5)
• Moneyline: Fighting Irish -2381, Boilermakers +1200
• Total: 51.5 points
• Prediction: Notre Dame 38, Purdue 16

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 3:30 p.m. ET
• TV Channel: NBC
• Location: South Bend, Indiana
• Box Score

No. 11 Oklahoma Sooners vs. No. 22 Auburn Tigers

Odds & Prediction

• Spread: Sooners (-7)
• Moneyline: Sooners -245, Tigers +200
• Total: 47.5 points
• Prediction: Oklahoma 30, Auburn 16

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 3:30 p.m. ET
• TV Channel: ABC
• Location: Norman, Oklahoma
• Box Score

No. 7 Florida State Seminoles vs. Kent State Golden Flashes

Odds & Prediction

• Spread: Seminoles (-44.5)
• Moneyline: Seminoles , Golden Flashes
• Total: 56.5 points
• Prediction: Florida State 39, Kent State 19

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 3:30 p.m. ET
• TV Channel: ACC Network
• Location: Tallahassee, Florida
• Box Score

No. 13 Ole Miss Rebels vs. Tulane Green Wave

Odds & Prediction

• Spread: Rebels (-12.5)
• Moneyline: Rebels -441, Green Wave +340
• Total: 61.5 points
• Prediction: Ole Miss 38, Tulane 20

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 3:30 p.m. ET
• TV Channel: ESPN
• Location: Oxford, Mississippi
• Box Score

Nebraska Cornhuskers vs. No. 21 Michigan Wolverines

Odds & Prediction

• Spread: Wolverines (-1.5)
• Moneyline: Wolverines -118, Cornhuskers -102
• Total: 47.5 points
• Prediction: Michigan 28, Nebraska 24

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 3:30 p.m. ET
• TV Channel: CBS
• Location: Lincoln, Nebraska
• Box Score

No. 18 Georgia Tech Yellow Jackets vs. Temple Owls

Odds & Prediction

• Spread: Yellow Jackets (-24.5)
• Moneyline: Yellow Jackets -2381, Owls +1200
• Total: 53.5 points
• Prediction: Georgia Tech 29, Temple 18

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 4:30 p.m. ET
• TV Channel: The CW
• Location: Atlanta, Georgia
• Box Score

No. 23 Missouri Tigers vs. South Carolina Gamecocks

Odds & Prediction

• Spread: Tigers (-9.5)
• Moneyline: Tigers -355, Gamecocks +280
• Total: 48.5 points
• Prediction: Missouri 30, South Carolina 22

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 7 p.m. ET
• TV Channel: ESPN
• Location: Columbia, Missouri
• Box Score

No. 19 Indiana Hoosiers vs. No. 9 Illinois Fighting Illini

Odds & Prediction

• Spread: Hoosiers (-6.5)
• Moneyline: Hoosiers -250, Fighting Illini +205
• Total: 51.5 points
• Prediction: Indiana 31, Illinois 21

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 7:30 p.m. ET
• TV Channel: NBC
• Location: Bloomington, Indiana
• Box Score

No. 4 Miami (FL) Hurricanes vs. Florida Gators

Odds & Prediction

• Spread: Hurricanes (-8.5)
• Moneyline: Hurricanes -325, Gators +260
• Total: 51.5 points
• Prediction: Miami (FL) 28, Florida 16

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 7:30 p.m. ET
• TV Channel: ABC
• Location: Miami Gardens, Florida
• Box Score

No. 20 Vanderbilt Commodores vs. Georgia State Panthers

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 7:30 p.m. ET
• TV Channel: ESPNU
• Location: Nashville, Tennessee
• Box Score

No. 3 LSU Tigers vs. Southeastern Louisiana Lions

Odds & Prediction

• Spread: Tigers (-48.5)
• Moneyline: Tigers , Lions
• Total: 60.5 points
• Prediction:

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 7:45 p.m. ET
• TV Channel: SEC Network
• Location: Baton Rouge, Louisiana
• Box Score

No. 8 Texas Longhorns vs. Sam Houston Bearkats

Odds & Prediction

• Spread: Longhorns (-39.5)
• Moneyline: Longhorns , Bearkats
• Total: 51.5 points
• Prediction: Texas 33, Sam Houston 15

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 8 p.m. ET
• TV Channel: SEC Network+
• Location: Austin, Texas
• Box Score

No. 25 USC Trojans vs. Michigan State Spartans

Odds & Prediction

• Spread: Trojans (-19.5)
• Moneyline: Trojans -1000, Spartans +650
• Total: 56.5 points
• Prediction: USC 38, Michigan State 26

How to Watch

• Game Date: Saturday, Sept. 20
• Game Time: 11 p.m. ET
• TV Channel: FOX
• Location: Los Angeles, California
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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