College Football Top 25 Week 10 2025 Predictions, Betting Odds & TV Schedule

The No. 9 Vanderbilt Commodores and the No. 20 Texas Longhorns take the field for one of 17 games on the college football slate in Week 10 that feature a ranked team.

Check out our betting preview for college football's Week 10.

Check out the full college football schedule on FOX Sports! Or visit FOX Sports' college football hub for everything you need to make the most of this season’s action.

Week 10 Betting Lines & Game Info

Rice Owls vs. No. 25 Memphis Tigers

Odds & Prediction

• Spread: Tigers (-14)
• Moneyline: Tigers -676, Owls +490
• Total: 48.5 points
• Prediction: Memphis 38, Rice 15

How to Watch

• Game Date: Friday, Oct. 31
• Game Time: 7 p.m. ET
• TV Channel: ESPN2
• Location: Houston, Texas
• Box Score

No. 1 Ohio State Buckeyes vs. Penn State Nittany Lions

Odds & Prediction

• Spread: Buckeyes (-18.5)
• Moneyline: Buckeyes -1205, Nittany Lions +750
• Total: 45.5 points
• Prediction: Ohio State 38, Penn State 8

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 12 p.m. ET
• TV Channel: FOX
• Location: Columbus, Ohio
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

No. 20 Texas Longhorns vs. No. 9 Vanderbilt Commodores

Odds & Prediction

• Spread: Longhorns (-3.5)
• Moneyline: Longhorns -185, Commodores +154
• Total: 48.5 points
• Prediction: Vanderbilt 26, Texas 25

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 12 p.m. ET
• TV Channel: ABC
• Location: Austin, Texas
• Box Score

SMU Mustangs vs. No. 10 Miami (FL) Hurricanes

Odds & Prediction

• Spread: Hurricanes (-10)
• Moneyline: Hurricanes -355, Mustangs +280
• Total: 50.5 points
• Prediction: Miami (FL) 33, SMU 17

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 12 p.m. ET
• TV Channel: ESPN
• Location: University Park, Texas
• Box Score

No. 22 Houston Cougars vs. West Virginia Mountaineers

Odds & Prediction

• Spread: Cougars (-13.5)
• Moneyline: Cougars -575, Mountaineers +425
• Total: 48.5 points
• Prediction: Houston 35, West Virginia 16

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 12 p.m. ET
• TV Channel: FS1
• Location: Houston, Texas
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Virginia Tech Hokies vs. No. 16 Louisville Cardinals

Odds & Prediction

• Spread: Cardinals (-10.5)
• Moneyline: Cardinals -395, Hokies +310
• Total: 53.5 points
• Prediction: Louisville 37, Virginia Tech 19

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 3 p.m. ET
• TV Channel: The CW
• Location: Blacksburg, Virginia
• Box Score

Maryland Terrapins vs. No. 2 Indiana Hoosiers

Odds & Prediction

• Spread: Hoosiers (-21)
• Moneyline: Hoosiers -1786, Terrapins +1000
• Total: 50.5 points
• Prediction: Indiana 36, Maryland 12

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 3:30 p.m. ET
• TV Channel: CBS
• Location: College Park, Maryland
• Box Score

Boston College Eagles vs. No. 12 Notre Dame Fighting Irish

Odds & Prediction

• Spread: Fighting Irish (-30.5)
• Moneyline: Fighting Irish -6667, Eagles +2000
• Total: 55.5 points
• Prediction: Notre Dame 47, Boston College 12

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 3:30 p.m. ET
• TV Channel: ESPN
• Location: Boston, Massachusetts
• Box Score

Florida Gators vs. No. 5 Georgia Bulldogs

Odds & Prediction

• Spread: Bulldogs (-7)
• Moneyline: Bulldogs -278, Gators +225
• Total: 50.5 points
• Prediction: Georgia 29, Florida 20

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 3:30 p.m. ET
• TV Channel: ABC
• Location: Jacksonville, Florida
• Box Score

Kansas State Wildcats vs. No. 13 Texas Tech Red Raiders

Odds & Prediction

• Spread: Red Raiders (-7.5)
• Moneyline: Red Raiders -298, Wildcats +240
• Total: 51.5 points
• Prediction: Texas Tech 32, Kansas State 21

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 3:30 p.m. ET
• TV Channel: FOX
• Location: Manhattan, Kansas
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

California Golden Bears vs. No. 15 Virginia Cavaliers

Odds & Prediction

• Spread: Cavaliers (-6.5)
• Moneyline: Cavaliers -230, Golden Bears +190
• Total: 52.5 points
• Prediction: Virginia 33, Cal 22

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 3:45 p.m. ET
• TV Channel: ESPN2
• Location: Berkeley, California
• Box Score

No. 21 Michigan Wolverines vs. Purdue Boilermakers

Odds & Prediction

• Spread: Wolverines (-21)
• Moneyline: Wolverines -1786, Boilermakers +1000
• Total: 49.5 points
• Prediction: Michigan 36, Purdue 13

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 7 p.m. ET
• TV Channel: BTN
• Location: Ann Arbor, Michigan
• Box Score

No. 7 Ole Miss Rebels vs. South Carolina Gamecocks

Odds & Prediction

• Spread: Rebels (-12.5)
• Moneyline: Rebels -500, Gamecocks +380
• Total: 56.5 points
• Prediction: Ole Miss 34, South Carolina 16

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 7 p.m. ET
• TV Channel: ESPN
• Location: Oxford, Mississippi
• Box Score

Nebraska Cornhuskers vs. No. 23 USC Trojans

Odds & Prediction

• Spread: Trojans (-4.5)
• Moneyline: Trojans -185, Cornhuskers +154
• Total: 59.5 points
• Prediction: USC 32, Nebraska 27

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 7:30 p.m. ET
• TV Channel: NBC
• Location: Lincoln, Nebraska
• Box Score

North Carolina State Wolfpack vs. No. 8 Georgia Tech Yellow Jackets

Odds & Prediction

• Spread: Yellow Jackets (-4.5)
• Moneyline: Yellow Jackets -198, Wolfpack +164
• Total: 59.5 points
• Prediction: Georgia Tech 32, NC State 25

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 7:30 p.m. ET
• TV Channel: ESPN2
• Location: Raleigh, North Carolina
• Box Score

No. 14 Tennessee Volunteers vs. No. 18 Oklahoma Sooners

Odds & Prediction

• Spread: Volunteers (-3)
• Moneyline: Volunteers -155, Sooners +130
• Total: 55.5 points
• Prediction: Oklahoma 30, Tennessee 29

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 7:30 p.m. ET
• TV Channel: ABC
• Location: Knoxville, Tennessee
• Box Score

No. 24 Utah Utes vs. No. 17 Cincinnati Bearcats

Odds & Prediction

• Spread: Utes (-10.5)
• Moneyline: Utes -441, Bearcats +340
• Total: 58.5 points
• Prediction: Utah 33, Cincinnati 19

How to Watch

• Game Date: Saturday, Nov. 1
• Game Time: 10:15 p.m. ET
• TV Channel: ESPN
• Location: Salt Lake City, Utah
• Box Score

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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