Indiana vs. Siena Prediction, How to Watch, Odds, Channel - Dec 22

Updated Dec. 22, 2025 8:27 p.m. ET

FOX Sports

The Indiana Hoosiers (9-3) take on the Siena Saints (9-3) on Monday, December 22, 2025 at 6 p.m. ET on Big Ten Network.

The Hoosiers take the court as overwhelming favorites against the Saints. The Hoosiers are favored by 22.5 points. The over/under for the matchup is set at 142.5.

Continue reading to get all you need to know before betting on the Indiana-Siena game.

Indiana vs. Siena How to Watch & Odds

When: Monday, December 22, 2025 at 6 p.m. ET
Where: Simon Skjodt Assembly Hall in Bloomington, Indiana
TV: Big Ten Network
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Hoosiers vs Saints Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Hoosiers	-22.5	-109	-111	142.5	-112	-108	-7143	+1838

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Indiana vs. Siena Prediction

Pick ATS: Siena (+22.5)
Pick OU: Over (142.5)
Prediction: Indiana 80, Siena 62

Learn more about the Indiana Hoosiers vs. the Siena Saints game on FOX Sports!

Indiana vs. Siena Betting Insights

Betting Line Implied Predictions

Per the spread and over/under, the implied score for the game is Hoosiers 82, Saints 60.
The Hoosiers have a 98.6% chance to claim victory in this meeting based on the moneyline's implied probability.
The Saints have a 5.2% implied probability to win.

Key Spread Facts

Indiana has put together a 6-6-0 ATS record so far this year.
Siena is 7-5-0 ATS this season.
Indiana has covered the spread three times this season (3-3 ATS) when playing as at least 22.5-point favorites.

Key Total Facts

Hoosiers games have finished with more than 142.5 points seven times so far this year.
Saints games have finished with over 142.5 points only two times this season.
The Hoosiers and Saints average 155.3 points per game combined, which is 12.8 more than the over/under for this matchup.

Key Moneyline Facts

Indiana is 9-1 in games when it was listed as the moneyline favorite (winning 90%).
Siena has lost both games it has played as underdogs this season.
Indiana has won all five games it played as a moneyline favorite with odds of -7143 or shorter.
Siena has not entered a game this season with longer moneyline odds than +1838.

Indiana vs. Siena: 2025-26 Stats Comparison

	Indiana	Siena
Points Scored Per Game (Rank)	85 (61)	70.3 (316)
Points Allowed (Rank)	66.6 (48)	63.2 (12)
Rebounds (Rank)	7.8 (317)	9.2 (218)
3pt Made (Rank)	10.8 (23)	5 (356)
Assists (Rank)	19.7 (11)	13.2 (269)
Turnovers (Rank)	10.3 (77)	10.3 (77)

Indiana 2025-26 Key Players

Hoosiers Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Lamar Wilkerson	12	18.7	2.7	2.7	1.6	0.2	3.5
Tucker DeVries	12	16.3	4.9	3.3	0.8	0.8	3.2
Tayton Conerway	12	11.6	3.3	4.4	1.8	0.3	0.8
Reed Bailey	12	10.7	4.3	1.8	0.3	0.3	0.1
Sam Alexis	12	8.2	5.3	1.4	0.3	1.1	0.1

Siena 2025-26 Key Players

Saints Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Gavin Doty	12	14.8	6.3	1.9	1.2	0.1	1
Justice Shoats	12	12.7	1.8	5.3	1.8	0.4	0.1
Brendan Coyle	12	10.4	4.5	1.3	0.9	0.3	2.1
Tasman Goodrick	9	9.7	7.3	1.3	0.8	0.9	0
Francis Folefac	12	8.6	4.3	1.2	1.3	1	0