Indiana vs. Siena Prediction, How to Watch, Odds, Channel - Dec 22

The Indiana Hoosiers (9-3) face the Siena Saints (9-3) on Monday, December 22, 2025 at 6 p.m. ET. The matchup airs on Big Ten Network.

The Hoosiers are an immense favorite against the Saints when the Hoosiers and the Saints square off. The Hoosiers are favored by 23.5 points. The game's point total is set at 141.5.

Continue reading to get the details before betting on the Indiana-Siena game.

Indiana vs. Siena How to Watch & Odds

• When: Monday, December 22, 2025 at 6 p.m. ET
• Where: Simon Skjodt Assembly Hall in Bloomington, Indiana
• TV: Big Ten Network
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

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Indiana vs. Siena Prediction

• Pick ATS: Siena (+23.5)
  
• Pick OU: Over (141.5)
  
• Prediction: Indiana 80, Siena 62

Learn more about the Indiana Hoosiers vs. the Siena Saints game on FOX Sports!

Indiana vs. Siena Betting Insights

Betting Line Implied Predictions

• Based on the spread and over/under, the implied score for the encounter is Hoosiers 82, Saints 59.
• The Hoosiers have a 98.5% chance to claim victory in this matchup per the moneyline's implied probability.
• The Saints hold a 4.8% implied probability to come out on top.

Key Spread Facts

• Indiana has put together a 6-6-0 record against the spread this season.
• Siena has put together a 7-5-0 record against the spread this season.
• Indiana has covered the spread three times this season (3-3 ATS) when playing as at least 23.5-point favorites.

Key Total Facts

• The Hoosiers games have had more than 141.5 points scored on seven occasions this year.
• Saints games have gone over 141.5 points on three occasions this year.
• The total for this matchup is 141.5 points, 13.8 fewer than the combined scoring average of the two teams.

Key Moneyline Facts

• Indiana has a 9-1 record in games when it was favored on the moneyline (winning 90% of those games).
• Siena has lost both games it has played as underdogs this season.
• Indiana has won all six games it played as a moneyline favorite with odds of -6667 or shorter.
• Siena has not entered a game this season with longer moneyline odds than +2000.

Indiana vs. Siena: 2025-26 Stats Comparison

Indiana 2025-26 Key Players

Siena 2025-26 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Indiana Hoosiers

Siena Saints