The Chargers have looked much better since Joey Bosa has been added to their defensive lineup, and Bosa was a factor in helping San Diego to Thursday's big win over the Broncos.
Here are the 10 best things to look for when Week 6 continues on Sunday, including Aaron Rodgers and the Packers getting ready for a showdown with the Cowboys.
Best chance for an upset
Cowboys over Packers: Green Bay at home should be a formidable foe for Dak Prescott and the Cowboys, but there's a chance the Packers offense may not be at full strength.
Eddie Lacy is dealing with an ankle injury, and his status for Sunday is uncertain. Backup RB James Starks is also on the injury report. If the Cowboys are able to load up against the pass, it could be a long day for Aaron Rodgers.
Best survivor pool pick
Tom Brady is 97-15 at home during the regular season since becoming the Patriots' starter, and it's his first home game of the season after serving that ridiculous four-game suspension.
Don't overthink this one.
Best individual matchup
Julio Jones vs. Richard Sherman: Sherman may not shadow Jones exclusively on Sunday thanks to Seattle's zone coverage, but there certainly will be times that the star receiver and speedy cornerback line up across from each other.
It's also a battle between the league's leading offense and its leading defense, and even if Jones is held in check, that doesn't guarantee success. He finished with just 29 yards receiving in Atlanta's Week 5 win over the Broncos.
USA TODAY SportsBrace Hemmelgarn
Best bad game
49ers vs. Bills: Buffalo seems to have found its stride after an 0-2 start, and should have little trouble with the 49ers when all is said and done.
But with Colin Kaepernick getting the start, he finally has a chance to make headlines for something other than his national anthem protest.
Best fantasy option
Drew Brees coming off of a bye week at home against a banged-up Panthers secondary should be a recipe for a monster performance.
According to ESPN, Brees has thrown for 695 yards and nine touchdowns combined in the two home games he's had after a bye week in the past five years.
Best chance for a shootout
Bengals at Patriots: We know Tom Brady is going to light up the scoreboard in his first home game of the season, but the Bengals have proven that they can move the ball, too.
Cincinnati hasn't consistently translated its success in the passing game into points, but Andy Dalton ranks third in the league in passing yards and A.J. Green is second in receiving yards.
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Best bet against the spread
The Bills are rolling with three straight victories, and are 7.5-point favorites at home over a 49ers team that is making a quarterback change for the first time all season.
San Francisco has lost its past four games by an average of 14 points, and we like Buffalo by two scores in this one.
(We're 2-3 on these picks this season.)
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Best chance for a low-scoring contest
Eagles at Redskins: Philadelphia has the league's second-ranked defense, and is allowing fewer than 13 points per game.
We expect the Eagles to get back on track on that side of the ball against Kirk Cousins in Washington on Sunday.
Best early game
Rams at Lions: The best games on Sunday's slate are the late ones, so L.A. visiting Detroit might be the best early game we've got.
The Lions are coming off of a big home win over the Eagles, while the Rams were easily handled at home by the Bills after their 3-1 start. This battle should be a close one.
Cowboys at Packers: This is a big game for both teams, for a variety of reasons.
In Green Bay, the Packers need every home win they can get in order to keep the 5-0 Vikings from running away with the division.
The Cowboys, meanwhile, may have even more on the line. A victory could ensure that Dak Prescott remains the starting quarterback, even if Tony Romo is healthy enough to return in a few short weeks.