Eli Manning has struggled to put up the monster fantasy lines that we've grown accustomed to over the years this season, but a matchup with the winless Browns could quickly change that. Manning has thrown for over 300 yards just once in his last seven games, but the Browns are 29th in passing yards allowed per game.
More importantly, the Browns are dead last in passing touchdowns allowed this season (25). If you pencil Eli in for the average stats the Browns allow, he'll have 266 yards with 2.5 touchdowns. The floor for Manning and Odell Beckham are very high, but don't forget guys like Will Tye and Sterling Shepard, either. Tye in particular should be headed for a big day, as the Browns have allowed the most receptions, yards and touchdowns to opposing tight ends this season.
Carson Palmer vs Atlanta
Carson Palmer owners may be hesitant to trot him out this week coming off a 198-yard performance, but keep in mind that came against Minnesota's tough pass defense. Week 12 features a much friendlier matchup with the Atlanta Falcons, a team that has been sliced up through the air all year. The Falcons have allowed the second most touchdowns and are dead last in the league in passing yards allowed per game with 283.
By all means, this should be a shootout. ARI-ATL has the highest projected point total of the week, which bodes well for Palmer's fantasy chances. Things have been rough as of late, but this is a prime bounceback spot for Palmer and Arizona's offense.
Rob Foldy-USA TODAY SportsRob Foldy
Jay Ajayi vs San Francisco
To the credit of the 49ers, the defense has been a little pluckier than usual as of late. San Francisco held Arizona to 80 yards on the ground two weeks ago, then at least kept it close against New England.
Still, the 49ers can get gashed by the run, and Miami is certainly going to make that the focus. The 49ers allow 179 yards per game on the ground for a whopping 5.2 yards per carry. The task of traveling across the country to stop Jay Ajayi, who has at least 77 yards in each of his last five games and is averaging 137 yards per game during that timespan, is way too much to ask. This is the biggest mismatch of Week 12.
Spencer Ware vs Denver
The Broncos have a reputation of being a defense you want to avoid at all costs, but that's not the case for opposing running backs. Denver is actually 27th in the league in rushing yards allowed, so teams that stay committed to the run can have a lot of success.
Typically, that would be right in the wheelhouse of the Chiefs, but Kansas City hasn't ran the ball a ton this year. In fact, the Chiefs are just 25th in rushing attempts this season. The prospects of Alex Smith throwing the ball 35 times should be enough to scare Andy Reid into getting Spencer Ware the ball a ton, so a 100-yard game certainly isn't out of the question. Ware has done that just once this season, but he's due.
Jake Roth-USA TODAY SportsJake Roth
Derek Carr vs Carolina
Speaking of imbalanced defenses, the Panthers fall in that category as well. Carolina is second in the league in rushing yards allowed, but just 26th in passing yards per game allowed. It's much easier to expose the young corners of Carolina than it is to pound the ball, which should mean big things for Derek Carr and his two star receivers, Amari Cooper and Michael Crabtree.
Carr has been a little boom or bust this year, but he's had success against teams with good run defenses. He threw for four touchdowns against Baltimore and hit the Chargers 317 yards and two scores. Against a Carolina team with a similar defensive profile, Carr could be in line for another big week.
Cary Edmondson-USA TODAY SportsCary Edmondson
Ravens defense vs Cincinnati
It's not all about injuries. Yes, the Bengals won't have A.J. Green or Giovani Bernard, which is a massive blow to the whole offense. Rex Burkhead and Brandon LaFell certainly don't strike fear into your heart.
But let's not sell the Ravens short, either. Baltimore has the top ranked run defense in the league, allowing just 76 yards per game on the ground. The Ravens have also allowed a league-low four rushing touchdowns. The Bengals will want to ride Jeremy Hill, but they might not find much success, and the Ravens have been solid against the pass this year as well. If you're in need of a streaming defense or if you're playing DFS, Vegas has the Bengals with the lowest projected point total in Week 12. Ride the Ravens.
Carson Wentz vs Green Bay
The wheels have come off the Carson Wentz bandwagon, but this is a great spot for him. The Packers have allowed 44.5 points per game over the last two weeks and are ranked 31st in QB rating allowed this season. You beat Green Bay through the air, and with Ryan Mathews questionable to play, the Eagles will likely lean on Wentz and the pass game to drive downfield.
If you're in need of a streaming QB, only Eli Manning has a more favorable matchup than Wentz in Week 12. The rookie should be in line to shine on Sunday night.