Oklahoma coach Bob Stoops said guard Jonathan Alvarez and cornerback Zack Sanchez are doubtful for Saturday's home game against Iowa State.
Alvarez got hurt last game against Kansas. The starting left guard said he could have returned but coaches decided not to risk it.
Sanchez was hurt two weeks ago against Texas Tech. The junior has 11 interceptions, including three this season.
Meanwhile, Stoops said linebacker Devante Bond and linebacker Jordan Evans have a "good chance of playing," Stoops said.
Bond has missed the past four games with an ankle injury. Evans last played three games ago vs. Kansas State.