Colts vs. Titans Prediction, Odds, Pick For NFL Week 6

The Tennessee Titans will visit the Indianapolis Colts on Sunday in a Week 6 NFL showdown on FOX.

Let’s take a look at the odds for Colts vs. Titans at FanDuel Sportsbook as of Oct. 18. 

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Moneyline

• Colts: -340
• Titans: +270

Spread

• Colts -7: -105
• Titans +7: -115

Over/Under

• Over 43.5: -118
• Under 43.5: -102

From FOX Sports Research: 

• Colts have dominated this matchup: Indianapolis has won six straight against Tennessee dating back to 2023, averaging 31.8 points per game during that stretch.
• Titans divisional struggles: Tennessee has lost 11 straight games against AFC South opponents, the NFL’s longest active divisional losing streak.
• Tennessee’s offensive woes: The Titans rank last in scoring (15.6 points per game) and total offense (256.6 yards per game) since the start of 2025.
• Ward still searching for wins: Cam Ward is 3-19 as a starter, the fewest wins through 22 career starts by any No. 1 overall pick in the common draft era.

How to Watch Colts vs. Titans

• Date: Sunday, Oct. 18, 2026
• Time: 1 p.m. ET
• TV: FOX
• Stream: Watch 3 days free on FOX One, FOXSports.com, FOX Sports App
• Location: Lucas Oil Stadium, Indianapolis, IN