Steven Pledger returned from a one-game suspension and scored 20 points as Oklahoma beat Coppin State 92-65 on Friday night.
Calvin Newell scored 14 points for the Sooners (2-0), and Romero Osby had 11 points and 10 rebounds.
Tony Gallo had 22 points and Logan Wiens added 13 for the Eagles (1-2).
Pledger didn't play in the season opener after being suspended for a violation of NCAA rules, playing without permission in a summer league game.
Oklahoma outrebounded Coppin State 61-27.
Before the game, a moment of silence was held in memory of four people, including Oklahoma State women's basketball coach Kurt Budke and assistant Miranda Serna, who died in a plane crash in Arkansas on Thursday.