Terrance Henry scored 21 points, Nick Williams added 18 and Mississippi snapped a three-game losing by beating LSU 72-48 on Saturday.
Henry, a 6-foot-9 senior, became the 33rd player in Ole Miss history to score 1,000 career points. He had one of his better games this season, making 7 of 12 shots from the field.
Ole Miss (16-12, 6-8 Southeastern Conference) never trailed, leading 34-24 at halftime before pulling away in the second half.
It was a crushing loss for LSU (17-11, 7-7), which had played its way into the NCAA Tournament conversation with a four-game winning streak. But the Tigers had a terrible offensive game, shooting just 31 percent (18 of 58) from the field.
Storm Warren led LSU with 13 points. Andre Stringer added 10 while Johnny O'Bryant had nine points and 11 rebounds.
The game was a stark contrast to the first meeting between the two teams on Jan. 7, when LSU drilled the Rebels 81-55 in Baton Rouge, La.
Ole Miss took the lead immediately on Henry's pull-up 3-pointer and never let up.
Henry had 13 first-half points, passing the 1,000-point mark on a pair of free throws. He's just the second Ole Miss player to have 1,000 career points and 100 career blocks.
Henry's had an up-and-down senior season, with some spectacular games mixed with virtual no-shows. But he played to his strengths against LSU, finishing with his left hand on drives to the basket and making open jumpers. He came into averaging a team-high 11.9 points.
Williams added 12 points in the first half, shooting 5 of 5 from the field, including two 3-pointers.
Ole Miss kept rolling in the second half. The Rebels stretched their lead to 43-26 on a short jumper by Williams with 13:04 remaining and were never threatened, rolling to a rare easy victory.
LSU coach Trent Johnson didn't see the end of it, receiving back-to-back technical fouls with 7:17 remaining. Ole Miss hit three of the four free throws assessed after the two technical to push its lead to 55-34.
LSU is used to playing low-scoring games, winning each of its previous four games with scores in the 60s. But the Tigers couldn't get into any sort of offensive rhythm against the Rebels' suffocating half-court defense.
LSU's leading scorer Justin Hamilton - who was averaging 13.6 points per game - didn't score until late in the second half when the game was already decided. He finished with two points and six rebounds.
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