Andre Stringer scored 16 points and LSU coach Trent Johnson won his 200th game as the Tigers defeated Centenary 78-36 on Wednesday night.
Stringer matched his season-high with four 3-pointers and Malcolm White added 14 points and seven rebounds for LSU.
Johnson, who is 200-151 in his career, coached at Nevada and Stanford before joining the Tigers in 2008.
Centenary (0-6) was held to 36 points, the fewest allowed by the Tigers since defeating Nicholls State 68-24 eight years ago.
Sparked by two 3-pointers from Aaron Dotson, LSU jumped out to an 8-1 lead in the first three minutes.
With Leo Davis, Logan Lowery and Maxx Nakwaash knocking down 3-pointers, Centenary pulled to 12-10.
The Tigers then went on an 18-5 run over the next 7 minutes to take control.
Ralston Turner and White provided most of the offense during that stretch. Turner made two field goals, one a 3-pointer. White scored the last six points to put the Tigers in front 30-15.
White and Stringer combined for the next nine points as LSU went into halftime with a 39-21 advantage. White had two free throws and a field goal, and Stringer sank two baskets, including a 3-pointer.
Centenary scored just five points in the first 10 minutes of the second half.
Davis led the Gents with 10 points.