Victor Oladipo scored a career-high 21 points on Sunday to help Indiana beat Chattanooga 78-53.
Jordan Hulls added 18 points and Verdell Jones III 16 for Indiana, which shot 50 percent from the floor and recorded seven blocks.
Omar Wattad led Chattanooga, playing its season opener, with 24 points. The Mocs held a 45-36 rebounding advantage.
The Hoosiers (2-0) have made 58 percent of their outside shots this season. They were coming off a 65 percent performance in Friday's opener against Stony Brook.
Indiana went on a 25-9 run to extend its lead to 61-33 midway through the second half.