Jeremiah Kelly hit six 3-pointers and scored a game-high 24 points to lead DePaul to an 80-70 victory over Mississippi Valley State on Monday.
Kelly hit five 3-pointers during a 3:30 span in the first half, part of a 25-12 run that opened a 46-34 halftime lead for the host Blue Demons (2-0).
DePaul, playing a rare on-campus game at McGrath-Phillips Arena, also got 19 points from Brandon Young, 16 from Cleveland Melvin and 10 from Charles McKinney.
The Delta Devils (0-2) were led by 13 points from Paul Crosby and 12 points apiece from Amos Studivant and Cor-J Cox.
Kelly's six 3-pointers were two shy of the school record set by Draelon Burns in 2008.