Fourth-seeded Jelena Jankovic of Serbia was upset by Sofia Arvidsson of Sweden 3-6, 6-3, 6-3 at the Brussels Open on Wednesday.
It was the latest setback on clay this spring for Jankovic, who failed to progress beyond the second round of three of the four tournaments she has played on the surface. Last week, she reached the quarterfinals in Rome for her best clay-court result this year.
Jankovic reached the semifinals at the French Open three of the last four years.
Second-seeded Vera Zvonareva survived an early scare to beat Galina Voskoboeva of Kazakhstan 2-6, 6-4, 6-3 and advance to the quarterfinals.
In an all-Belgian match, sixth-seeded Yanina Wickmayer edged 17-year-old qualifier Alison Van Uytvanck 7-6 (2), 6-4. Wickmayer will play in the quarterfinals against either top-seeded Caroline Wozniacki or American Varvara Lepchenko, who play late Wednesday.
Eighth-seeded Peng Shuai of China joined the Russian in the last eight, beating qualifier Abigail Spears of the United States 6-2, 6-0.
The clay-court tournament is the last warmup for the French Open, which begins Sunday.
