MELBOURNE, Australia (AP) There was some symmetry about the fourth-round exits of top-ranked Andy Murray and Angelique Kerber at the Australian Open.
Both had the top seeding for the first time at a Grand Slam tournament. Both went out on the same court and, at least on paper, the same day.
It was tough at the top on Sunday: Five-time finalist Murray lost 7-5, 5-7, 6-2, 6-4 to No. 50-ranked Mischa Zverev in the afternoon match on Rod Laver Arena, and defending women's champion Kerber lost 6-3, 6-2 to CoCo Vandeweghe in an upset that finished at six minutes past midnight.
It was the first time since the French Open in 2010 that both top-seeded players went out in the same round. In the quarterfinals at Roland Garros that year, Roger Federer lost to Robin Soderling and Serena Williams lost to Sam Stosur.
Murray and Kerber didn't make it to the second week.
Vandeweghe had never been past the third round at the season-opening Grand Slam, and lost in the first round here last year. But she pounded Kerber with a powerful forehand, clubbing 13 of her 30 winners from that wing.
Kerber saved a match point in the first round last year before winning her first major title, beating Serena Williams in the final. She replaced Williams atop the rankings after winning the U.S. Open.
Murray lost the final here to six-time champion Novak Djokovic last year, but finished 2016 at No. 1 after a strong finish to the season that included titles at Wimbledon, the Olympics and the ATP Finals.
He was undone by some old-school serve and volley from Zverev, who played the match of his life. He'll now meet 17-time major winner Federer in the quarterfinals.
In between the upsets was pretty rocky, too. Federer was down 5-1 in the first set against Kei Nishikori but found a way to fend off the 2014 U.S. Open finalist, who was cramping and needed late treatment on his back, 6-7 (4), 6-4, 6-1, 4-6, 6-3.
It was his 200th career win over a top 10 player.
Federer was ecstatic. ''It was about staying with him. ... almost going down 6-0, I thought `It's not going to get any worse from there,''' said Federer, on the comeback from six months on the sidelines to repair his injured left knee. ''Huge win for me in my career.''
Murray was stunned.
''Right now I'm obviously very down because I wanted to go further in this event,'' Murray said. ''I've had tough losses in my career in the past. I've come back from them. This is a tough one.''
Murray's exit follows the second-round departure of Djokovic, beaten in the second round by No. 117-ranked wild-card entry Denis Istomin.
It's the first time since 2002 that the top two seeds in the men's draw haven't reached the Australian Open quarterfinals, and the first time at a Grand Slam since the French Open in 2004.
The absence of Djokovic and Murray certainly opens up it up for others.
U.S. Open champion Stan Wawrinka, who had his major breakthrough here in 2014, is a growing contender after beating Andreas Seppi 7-6 (2), 7-6 (4), 7-6 (4). He'll play a quarterfinal against 2008 Australian Open finalist Jo-Wilfried Tsonga, who beat Dan Evans 6-7 (4), 6-2, 6-4, 6-4.
In the bottom half of the draw, 14-time major winner Rafael Nadal is the only man still in contention who has won a Grand Slam title.
The top half of the women's draw is open, too. Venus Williams returned to the quarterfinals for the ninth time with a 6-3, 7-5 win over No. 181-ranked Mona Barthel.
The seven-time major winner next plays No. 24-seeded Anastasia Pavlyuchenkova, who beat No. 8 Svetlana Kuznetsova 6-3, 6-3.
French Open champion Garbine Muguruza beat Sorana Cirstea 6-2, 6-3 and will next play Vandeweghe - they're both in the quarterfinals at Melbourne Park for the first time.
Kerber's loss contined a poor run since she won the U.S. Open last September. She's played seven tournaments without winning a title, only reached one final, and was 5-7 against top 50 players.
The bigger upset of the day, then, was produced by Zverev, the older and apparently lesser-talented brother of Alexander who had never gone past the third round of a major and was appearing at only his third Grand Slam in six years.
Zverev attacked Murray, unsettling his natural baseline game, and won 65 of 118 points at the net.
He made some stunning, lunging volleys on clutch points, but for him it was all a blur.
''It was like I was in a little coma, I just served and volleyed my way through,'' Zverev said. ''Honestly there were a few points where I don't know how I pulled it off.''
Murray couldn't do a lot to counter it.
''It's the shots he was coming up with when he did come forward.'' Murray said. ''He came up with some great pickups, you know, reflex volleys especially at the end when it was tight.''
Murray had reached the quarterfinals or better on his previous seven trips to Australia but never won the title - losing finals in 2010 to Federer and in `11, `13, `15 and `16 to Djokovic.
He had not lost to a player ranked as lowly as Zverev at a major since his loss to No. 51 Juan Ignacio Chela here in 2006. It was also the earliest exit by a top-seeded player at the Australian Open since Lleyton Hewitt in 2003.
