Defending champion Novak Djokovic was stunned by 55th-ranked Jiri Vesely 6-4, 2-6, 6-4 in the second round of the Monte Carlo Masters on Wednesday.
It was his first loss in a completed match since November. He retired from a match in February with eye infections.
The top-ranked Djokovic saved a match point when he was serving against Vesely in the ninth game. But the Czech, who had never beaten a top-10 player, sealed the win on his second match point in the next game.
It was Djokovic's first loss in a Masters-level event since August. Since then he'd won nine of 10 events, including two grand slams, four Masters titles, and the ATP Finals.
Earlier, eight-time Monte Carlo champion Rafael Nadal dropped serve twice and still beat Aljaz Bedene of Britain 6-3, 6-3 in the second round.
