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Samba was the subject of a £5million bid from QPR last week, and has also been linked with a move to Tottenham.
The centre-back's omission from the side for Saturday's 2-1 FA Cup third-round defeat at Newcastle heightened speculation, although Kean maintains that was due to injury.
As for Yakubu, who has scored an impressive 13 goals in 18 matches this season, the Nigerian was surprisingly an unused substitute at St James' Park, again leading to suggestions he could be leaving.
But a defiant Kean said: "The message is simple - the Yak is our player, he is performing very well, he has done fantastic for us, he is not for sale.
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"He is very happy, he is carrying a couple of knocks, so we rested him for next week."
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