Dundee United have doubts over two of their Irish defenders ahead of the Scottish Cup tie at Stranraer.
Sean Dillon (thigh) and Gavin Gunning (ankle) will face late fitness tests prior to kick-off.
But fellow Irishman Willo Flood is expected to recover from an ankle knock picked up in the 2-1 SPL defeat by Motherwell earlier this week.
Gary Mackay-Steven remains on the sidelines after breaking a bone in his hand.
City, since the takeover by Abu Dhabi-based billionaire Sheikh Mansour, have spent £500million on players in just over five years, won the title, the FA Cup and have played in the Champions League.
The Toffees, who have not won a trophy since 1995, are still struggling to find someone to invest in them after a number of years searching and have traditionally had to make one big sale every season to balance the books.
Despite that they are enjoying their best start to a campaign for some time although they have recently dropped out of the top four.
"It (the match) is maybe the ones who have and the ones who have not possibly but when we cross the white line tomorrow no-one is thinking what they've got and what we've not got," said Moyes.
"At the end of the day it is 11 versus 11 and if we can continue the record of making it hard for them and upsetting them then we will."
Moyes' recent record against City is good, particularly, at the Etihad Stadium where last year's defeat came after victories in four successive seasons.
Mancini's side are undefeated in 36 Premier League home matches, dating back almost two years to December 2010, but that does not concern Moyes.
"We didn't have a good record there against them last year because we lost but we played well and did a job on them," said the Toffees boss.
"They were very good at that time and we did a man-marking job on David Silva and I think we got to about 68 minutes before we conceded.
"You have to think where Everton were last season compared to now.
"We were a different team and we were in a different mindset then - but so were Man City because they were really flying.
"It has completely changed around: we are different now, we feel different about ourselves and have different players so we can approach the game in a different fashion.
"But can you tell me any team who attacks Man City? I went to watch them against Chelsea, the European champions, and I wouldn't say they really attacked them.
"We will try to have a go at them but there are teams maybe better than us who can't do it but we'll go there and try to make it work."
Everton will most likely be without Leighton Baines, who injured a hamstring in the midweek draw with Arsenal, and that leaves a huge hole not only at full-back but down the entire left flank.
Moyes could play Bryan Oviedo, whom he brought in during the summer, there or take the more pragmatic approach and shift centre-back Sylvain Distin.
"You can see it's not easy to replace good left-backs and that is why we got someone in early because we've not had any cover for Leighton," said the manager.
"He is can be our best attacker at times. His combination play is very good and a big part of the team."
Everton have drawn six of their last eight matches, which has resulted in their slip from second place in September to their current sixth spot.
Moyes knows his side need to find more goals to kill off games and is looking for striker Nikica Jelavic to rediscover his early-season form after finding the net just once in his last seven appearances.
"We want him to hold the ball up, bring people into the game, and he created one or two opportunities against Arsenal and had one great made by himself where he should at least hit the target," he added.
"That was a bit more like it, it was more encouraging, and let's hope he continues that.
"At the moment Felli (Marouane Fellaini) is getting the goals but we need him and Jela to end up getting quite a lot between the two of them.
"I said to the lads we need to keep making chances. In the opening six to 10 games people were saying Everton had created more chances than any club in Europe never mind England.
"We have not been doing bad but in recent weeks we have not been as good making and taking those opportunities."
Caley Thistle have enjoyed one of the best weeks in their history with victories on the road against Celtic and Aberdeen putting them in the top three of the Scottish Premier League.
But local bragging rights and cup progression are now at stake as they make the much shorter journey to Dingwall.
Butcher is confident his players will come down from the highs of Parkhead and Pittodrie when they run out at the Global Energy Stadium on Saturday.
The former England captain said: "When the draw was made, if it had been a lower-league club then there was a grave danger of the players not approaching the game in the right frame of mind.
"But because it's Ross County away from home, the first ever Highland derby in the Scottish Cup, the players know it's a very, very big game and on the same level as the ones we have played before, if not higher.
"They have managed to put the Celtic and Aberdeen game to the back of their minds because they are history now and have no bearing on this game. It stands alone and it should be a cracker. The players are right up for it."
Caley Thistle's new-look team won the first SPL meeting between the local rivals with a 3-1 home victory in September despite the visitors having much more experience of the game, with several former Inverness players in their team.
And Butcher feels their form will have no relevance in the latest encounter.
"A lot of our boys haven't been there," he said. "Only Ryan Esson and Richie (Foran) have been there before.
"I haven't won there as Caley Thistle manager. I have got a draw there. But it was the same at Celtic Park last week and Billy McKay and the rest of the team turned that round.
"Previous history and the previous match, which we won 3-1, doesn't count. This stands alone, it's a one-off cup tie. It will be a cracking match, a cracking ground and a brilliant atmosphere.
"No-one has played in a Highland derby in the Scottish Cup. No-one has any experience of it. So what has happened before has no bearing.
"No matter what both teams have done this week, what the form is, what the history is, counts for nothing. How you go about it on the day is key to it.
"For me, no-one is the favourite. Ross County are at home but cup ties are major levellers."
The Dingwall side progressed all the way to the final a couple of years ago - taking high-profile scalps along the way - before eventually losing to Dundee United at Hampden.
Adams would love to see his side have another crack at silverware this time around but knows the visit of Caley Thistle is a tough opener.
He said: "We want to get back to another final like we did in 2010.
"It was a difficult progression through the rounds and we had to beat the likes of Hibernian and Celtic on the way.
"We've got a tough one to start with against Inverness.
"It's a tough hurdle but we're in positive mood and we go into the game ready for them."
Inverness claimed the bragging rights in the last Highland derby between the two sides, when they claimed a 3-1 victory in the Scottish Premier League in October.
Adams said: "I don't think we'll have to say much from a motivational point of view on Saturday.
"The players will be motivated enough and ready to go.
"We'll just have to be aware of Inverness' threats and try to exploit their weaknesses."
The County boss hopes home advantage can make all the difference in tomorrow's tie.
He said: "We're looking forward to the game, especially with it being at home.
"It's a good opportunity for us to try to progress to the next round of the cup and Inverness will be thinking the same way.
"We've done well at home against Inverness before, with a win and a draw.
"If we can take that mentality into the cup game, we'll do well.
"Inverness have done very well of late and have managed to put a run together.
"But the players want to win the match and progress to the next round and they'll be focused."
Houston's men lifted the trophy two years ago and set out on another potential road to Hampden when they make the trip to Stair Park to take on the Second Division hopefuls.
United are strong favourites to progress despite their indifferent league form of late, but Houston will not allow any complacency to creep into their thinking.
Houston said: "We know we face a very difficult tie.
"It's there for all to see and we won't be thinking for a minute that is it going to be easy.
"The last thing we want is on the receiving end of some sort of shock which happens in the cup each season.
"Stranraer have a good mixture of youth and experience and any reports we've had done on them say they are a capable side.
"I'll be stressing that to the players again before kick-off so nobody in our camp will be under any illusions.
"We should progress to the next round if we play like we can.
"But first and foremost we have to be prepared to go and battle and earn the right to get through."
United's glory run all the way to Hampden in 2010 began with a hard-fought narrow win over lower league Partick Thistle, and they know they may need more of the same to see off minnows Stranraer.
Houston said: "Nobody ever gets it easy in the cup.
"Thinking back to the year we won it, we had to work extremely hard to get through against Partick Thistle before going on a great run.
"This will be Stranraer's cup tie as far as they are concerned so we have to be wary of that from the very start.
"It's a tight playing surface down at Stranraer and you'd expect them to throw everything at us.
"But we have to start the game better than we have done in recent weeks.
"We've had this tendency to keep losing the first goal which gives you a mountain to climb for the rest of the game.
"It's time that changed and there's no better time for it to do so than at Stranraer.
"It's up to us. I want to see us take command from the start and play like we know we can."
The Northern Ireland international came close to playing at the national stadium with former club Celtic, whom he left for the Dons in the summer, making the squad on a couple of occasions.
Buoyed by eight goals for Aberdeen this season in an unfamiliar centre-forward role, the 25-year-old is looking to take the next step with Craig Brown's side, although he is wary of the in-form Steelmen who have won their last three away games.
"It is a period of transition for us, in a couple of years we want to be challenging for trophies on a regular basis, that is what the fans deserve," McGinn said.
"But it would be nice to get to Hampden this season, that is a personal goal of mine.
"I was in a few Celtic squads for semi-finals and finals but never got to play there so that would be extra special.
"I played in cup finals with Derry City and my first club Dungannon Swifts reached a cup final, although I was disappointed to be left out for that.
"It was disappointing to go out of the League Cup to St Mirren so we want to go as far as we can in this competition.
"But we can't look past Motherwell. They are doing very well at the moment and come off a couple of great results against Inverness and Dundee United, so they will be on a high.
"Everyone knows the importance of the game. It is going to be a typical cup tie and it would be nice to get the first goal to settle us.
"We were down 3-1 to Motherwell earlier in the season at Pittodrie in the league and had to fight hard to get back to 3-3, so we know how difficult it will be."
After being a bit-part player at Celtic Park, McGinn is thriving on regular football and the added responsibility which comes with a new-found reputation for scoring.
"I'm delighted to be playing week-in, week-out and it is always nice to chip in with a goal," said October's Scottish Premier League Player of the Month.
"I just have to find the consistency now.
"The fans expect me to score so I hope I can keep it going, but even if I don't score I will be working hard to contribute to the team.
"I haven't been renowned for my goalscoring, having played wide for most of my career. So if someone had offered me eight goals at this stage of the season I would have bitten their hand off for it.
"I am delighted but I always had it in me. At all my previous clubs I got into good positions but I have been working hard on my finishing."
The Dark Blues, who returned to the top flight this season following a seven-year absence, have been battling at the foot of the league but have a break from the rigours of their survival battle when they head to Almondvale for Saturday's fourth-round tie.
Smith, therefore, wants them to take advantage of this weekend's break from their dogfight in the hope it can spark a cup run.
Smith said: "It's been tough this season and we've had to learn the hard way at times.
"We knew all along it was going to be like that but this is something of a break from it all.
"There are stresses and strains in the SPL so this will be a different sort of experience from that but it's still not going to be easy against a good side like Livingston.
"I have a group of players who always give their best and they will want to stay in the cup for as long as possible.
"I know what it takes to get all the way to a final, which I will be stressing to the players beforehand.
"To be fair, they know the importance of the tie and have been preparing all week towards getting a positive result."
Dundee will be favourites to book their place in the next round but Smith is adamant they will not be underestimating their First Division opponents.
He added: "We've had them watched on a few occasions.
"We know what they have to offer as a team with some good players all over the pitch.
"We will respect Livingston the way they we respect every other team which we come up against.
"That's what we always do and this is no time for approaching things in any different way.
"But if our players show the sort of attitude and commitment levels they have done in recent weeks then we will give ourselves every chance of winning the tie.
"But we all know how the cup works so we have to be on our toes from the very start and go about our job in a professional manner.
"I think they like to play the game in an open manner much like ourselves.
"That means it has got the makings of a good cup tie.
"But we will only enjoy it if we can get the right result to put us into the next round of the competition. That is the most important thing as far as we're concerned."
The Celtic boss was speaking after his Kilmarnock counterpart Kenny Shiels and St Johnstone manager Steve Lomas found themselves in hot water with the SFA this week.
Lomas was handed a six-match ban for his reaction towards referee Iain Brines over a decision during his side's draw at Parkhead this month, with a suspended two-game punishment also invoked.
Lennon's comments though, pertained more to Shiels who was issued with two notices of complaint by Lunny, one of which was for allegedly breaching three disciplinary rules as a result of comments he made in a radio interview and newspaper articles following their defeat to Inverness on November 3.
One of the accusations was that Shiels made comments that "impinge upon the character of a match official by suggesting that the match official may bear a grudge against you should you answer a question relating to decisions taken by him".
The Killie boss also faces a misconduct charge for being sent to the stand for dissent during last weekend's defeat by St Johnstone.
Lennon, ahead of Saturday's Scottish Cup fourth-round tie at home to Second Division side Arbroath, called for some instruction from Lunny in respect of post-match interviews.
"The last place you want to be is in the stand, as I know from my own experience," said the Northern Irishman.
"Steve, certainly, will learn from this.
"But I don't know where, as managers, we draw the line.
"I think Vincent Lunny should come and speak to managers because at the end of the day we are the ones who are brought up in front of him and the SFA disciplinary panel.
"I think Vincent needs to spell out the guidelines, what we can and can't say regarding referees in post-match interviews.
"That would give us a clearer indication and maybe make us count to 10 a little bit more in the heat of the moment.
"I do have a lot of sympathy for all managers in that situation.
"I was removed from the game at Ibrox last year, unjustifiably so, I felt, and Kenny is obviously feeling that sense of injustice as well.
"So we need the disciplinary procedure spelt out to us in black and white.
"You do have a spell after the game when you are speaking to your players and then you go out and speak to the press so you do have time (to calm down) but at times managers tell the truth.
"I don't know if Kenny was offensive in any way in his post-match interview or to the referee, but we will end up talking in cliches then because we will be protecting ourselves."
Lennon admits it would be "fair to say" Celtic fans will see a different side start against the Red Lichties than they will against Spartak Moscow in their Champions League Group G decider at Parkhead next Wednesday night.
The Hoops need a better result against the Russians than Benfica get against Barcelona in the Nou Camp.
The former Celtic skipper said: "Obviously we have Spartak in mind but I will be putting out a strong team tomorrow.
"It is important to keep momentum going for Wednesday night.
"There are players ready to play and Emilio Izaguirre and Thomas Rogne will come into contention.
"But there will be players who play tomorrow who also play on Wednesday night.
"I am not going to change 11 players just for the sake of it. I want to progress in this competition, I don't want to throw all my eggs into one basket.
"But there will be plenty of players having a rest between now and Wednesday.
"The Spartak game is certainly defining in terms of qualification for the last 16 but that is just the one competition.
"There is a lot of football to be played, we are not even halfway through the domestic calendar yet.
"But in terms of European football, it is a defining game, it will differentiate whether we play in the Europa League or the Champions League and we would all want to be in the Champions League.
"It is out of our hands to a certain extent.
"What we have to do is win the game and make Benfica win in the Nou Camp and if they do that then credit to them."
