After Saturday's FA Cup defeat to Liverpool, an encounter with Tony Pulis' battlers would not normally be viewed as the ideal method of recovery.
Yet, United are one of the few sides to have emerged relatively unscathed in their meetings with Stoke.
A draw at the Britannia Stadium in September represented the first points dropped against the Potters since they were promoted to the Premier League in 2008.
And United must go back to 1976 for their last Old Trafford loss to Stoke, courtesy of a late goal from City legend Alan Bloor.
"You know what Tony Pulis's team will be like, they are the same all the time," said Ferguson.
"They will be 100% committed and they always get stuck in. You have to cope with that.
"To be honest, I always enjoy it to.
"It was like when we used to play Wimbledon. No-one used to look forward to playing against them but my team started to because it was a physical challenge and in terms of taking the ball and playing football.
"Stoke are a different team altogether but they still have the same qualities of never giving in, so it is always a good challenge for us."
The weekend setback has placed even more emphasis on the next few weeks, when Chelsea, Liverpool and Tottenham must all be faced.
With the Europa League - which United are competing for as a direct result of their Champions League failure - as the only other trophy they can win, focus on the domestic campaign has to be total.
Three points behind Manchester City already, United cannot afford to slip any further adrift if they are to gain any advantage from their vast experience over the run-in.
"It is a big programme," said Ferguson.
"From the middle of January until we go to Tottenham, it looked quite a daunting programme.
"But when you go back years ago in our title campaigns, we have always had periods of must win-games in a row and that is what we have here.
"It is important to keep on City's coat-tails and hopefully come the important part of the season, we still are."
Although Ashley Young, Tom Cleverley and Anderson are all inching closer to full fitness, it seems Nani may be out for a significant period with a foot injury.
Wayne Rooney and Phil Jones are continuing to nurse ankle problems, so the main avenue of good news from the treatment table could come from Rio Ferdinand, who has returned to training after a back spasm, even if Ferguson felt unable to risk an appearance off the bench at Anfield.
Yet again this season, United find themselves having to haul themselves off the floor, just as they did after that 6-1 hammering by Manchester City in October, and their shattering Champions League humiliation by Basel two months later.
And, speaking on Monday, Jonny Evans emphasised the kind of mentality that is being demanded of his players by Ferguson once more.
"We responded really well after the 6-1 defeat against City and then the losses against Blackburn and Newcastle around the turn of the year," Evans told the club's website.
"We went on a great run after the City game and then after New Year we've beaten both City and Arsenal away. That's what this team does.
"Every player knows what is expected. When you're at Manchester United you know defeats like that aren't acceptable.
"We don't need anybody else to tell us that. We know it deep down."
