Didier Drogba will have ambitions of a third successive Premier League hat trick when Chelsea visits Wigan, the team it routed 8-0 to win the title on the final day of last season.
Wigan began this season with a humbling 4-0 home loss to newly promoted Blackpool but beat Chelsea 3-1 at the DW Stadium last September in one of the shock results of the campaign. It ended Chelsea's run of seven straight victories and was the first defeat of manager Carlo Ancelotti's reign.
"It is always hard to play at Wigan," Chelsea striker Nicolas Anelka said. "It is going to be maybe even harder because they lost 4-0 there in their game last weekend.
"We have to come back with three points and also we have to play our game and to do the same as last week."
Anelka's favored position is as a striker but with Drogba showing ominous early form, the Frenchman is having to settle for a place on the right wing in Ancelotti's 4-3-3 formation.
Drogba was the top scorer in the Premier League last season and netted a 23-minute hat trick against West Brom to show he is one of the favorites to top the goalscoring charts this season, too.
The powerful striker has said he is playing with more freedom after recovering from surgery to cure a nagging hernia injury that has affected him for the past six years. And his treble last weekend came three months after the hat trick he scored against Wigan in the championship-clinching win at Stamford Bridge.
Chelsea is in fine form going forward but also has been tight at the back, having gone 406 minutes without conceding a league goal.
Manchester United is again expected to be Chelsea's main challenger for the title but will have to do without Rio Ferdinand for another five weeks as the England captain recovers from medial ligament damage suffered just before the World Cup.
"We are still thinking the end of September for Rio," United manager Alex Ferguson said Friday. "It was a medial ligament problem rather than a cruciate, so the recovery time is exactly what we thought."
United began the season with a 3-0 home win over Newcastle but has lost to Fulham at Craven Cottage the last two seasons, conceding five goals and not scoring a goal.
Manchester City and Liverpool both won 1-0 in Europa League playoff first legs on Thursday and meet at Eastlands on Monday looking to claim their first victories in the league this season, after opening-weekend draws.
City manager Roberto Mancini completed his summer signing spree with the capture of James Milner from Aston Villa on Wednesday for a reported 26 million pounds ($40.6 million) and the England midfielder could make his debut against Liverpool.
Italy forward Mario Balotelli, who made a dream debut for City by coming off the bench to score the winner in the 1-0 victory over FC Timisoara on Thursday, also could start.
Liverpool is without the suspended Joe Cole, who compounded his sending-off in the 1-1 draw against Arsenal on his league debut by missing a penalty in the club's 1-0 win at home to Trabzonspor in the Europa League.
On Saturday, Arsenal hosts Blackpool, Birmingham is home to Blackburn, Wolverhampton goes to Everton, West Brom hosts Sunderland and Tottenham travels to Stoke.
Newcastle is at home to Aston Villa in Sunday's other match.
