Wolves manager Dean Saunders admits it is unlikely that his side will be able to avoid relegration into League One on the final day.
Saunders' men head to Brighton knowing only a victory will keep their hopes of staying up alive, and even then they are still reliant on results elsewhere going in their favour.
The Molineux boss believes his side are capable of achieving the great escape on Saturday but has already hinted he has started to think about the potential of next season in League One.
He told the club's official website: "It is going to be touch and go. It is unlikely but not impossible.
"If we win our game and Barnsley and Peterborough lose, it is going to be within a goal or two.
"We've just got to go there with belief that we can win our game; then we need Crystal Palace to turn on a performance against Peterborough.
"We have to try and make something happen, and if it doesn't we will start again."
Centre-half Cuthbert, 25, has made more than 50 appearances for the O's despite missing this season's run-in with a fractured metatarsal, and put pen to a two-year contract.
The club have also offered new deals to defenders Romain Vincelot and Elliot Omozusi and striker David Mooney.
But they are the only four players who will be out of contract in the summer to be offered fresh terms.
Former QPR duo Cook and Rowlands will be released along with utility man Leon McSweeney, striker Charlie MacDonald, goalkeeper Lee Butcher and midfielder Jimmy Smith, who scored in Orient's final-day 1-1 draw against Oldham.
